文献类型：期刊文献

英文题名：Design, synthesis, X-ray crystal structure and antibacterial activity of ferulic acid derivatives bearing sulfonamide moiety

作者：Bai, Song Wan, Suran Wu, Rong Li, Miao Wang, Fang Tang, Shouying Chen, Lijun Wei, Xian Feng, Shuang Zhang, Miaohe

第一作者：柏松

通信作者：Bai, S[1];Wan, SR[1]|[14440625ef7c60d4893dd]柏松;[144409b159ce598c03843]柏松;

机构：[1]Guizhou Ind Polytech Coll, Guiyang, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang, Peoples R China;[3]Guizhou Univ, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang, Peoples R China.|贵州理工学院化学工程学院;贵州理工学院化学工程学院

年份：2025

外文期刊名：PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

收录：;Scopus(收录号：2-s2.0-105008480246);WOS:【SCI-EXPANDED(收录号:WOS:001512208700001)】；

基金：The authors gratefully acknowledge the High School Science and Technology Talent Support Project of Guizhou Province, China (Grant No. Qian Jiao He KY Zi [2021]037), Science and Technology Planning Project of Guizhou Province (Grant No. Qian Ke He Ji Chu ZK [2022]Zhong Dian 025), Basic Research Project of Guizhou Province (Grant No. Qian Ke He Ji Chu zk [2025]Mian Shang 003), High-Level Talent Initial Funding of Guizhou Industry Polytechnic College (Grant No. 2023-RC-01), The Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University (Grant No. Qian Jiao Ji [2022]433), Guizhou Provincial Department of Education Youth Science and Technology Talent Growth Project (Grant No. Qian Jiao Ji [2024]292 Hao). Guizhou Industry Polytechnic College Science and Technology Innovation Team Project (Grant No. 2023CXTD03), Guizhou Industry Polytechnic College Faculty-level Research Project (Grant No. 2023ZK10 & Grant No. 2023ZK11), The Young Science and Technology Talents Development Program of Education Department of Guizhou Province (Grant NO. Qian Jiao He KY Zi [2022]346 Hao), the academic new seedling cultivation and exploration and innovation project of Guizhou Institute of Technology (No. GZLGXM-20).

语种：英文

外文关键词：Antibacterial activity; antibacterial mechanisms; ferulic acid derivatives; sulfonamide; synthesis

摘要：A total of 28 new ferulic acid derivatives bearing the sulfonamide moiety were designed and synthesized, followed by an evaluation of their antibacterial activities. The structures of the synthesized compounds (B1 - B28) were fully characterized using 1H NMR,13C NMR, and HRMS techniques. Among them, the structure of compound B11 was further elucidated through X-ray single-crystal diffraction analyses. Bioassay results indicated that several target compounds exhibited significant inhibitory activity against the tested plant pathogens in vitro. Notably, compound B28 demonstrated the highest resistance to Xanthomonas oryzae pv. oryzicola (Xoc), with an EC50 (half-maximal effective concentration) value of 28.6 mu g/mL, which was more than twice as effective as the control agents zinc thiazole (EC50 = 74.4 mu g/mL) and thiodiazole copper (EC50 = 97.1 mu g/mL). Mechanistic studies revealed that B28 enhances bacterial membrane permeability and disrupts cell morphology. This work highlights promising candidates for agricultural antibacterial applications.