文献类型：期刊文献

英文题名：Biocompatible zwitterionic phosphorylcholine polymers with aggregation-induced emission feature

作者：Xie, Gaoyi Ma, Chunping Zhang, Xiqi Liu, Hongliang Guo, Xingxing Yang, Liutao Li, Yang Wang, Ke Wei, Yen

第一作者：谢高艺

通信作者：Ma, CP[1];Zhang, XQ[2];Wei, Y[2];Zhang, XQ[3];Wei, Y[3]|[144404c59386af0196f94]马春平;

机构：[1]Guizhou Inst Technol, Coll Chem Engn, Guiyang 550003, Guizhou, Peoples R China;[2]Guizhou Inst Technol, Coll Mat & Met Engn, Guiyang 550003, Guizhou, Peoples R China;[3]Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Bioinspired Mat & Interface Sci, Beijing 100190, Peoples R China;[4]Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China;[5]Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China;[6]Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

第一机构：贵州理工学院化学工程学院

通信机构：corresponding author), Guizhou Inst Technol, Coll Mat & Met Engn, Guiyang 550003, Guizhou, Peoples R China;corresponding author), Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China;corresponding author), Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China.|贵州理工学院材料与冶金工程学院;贵州理工学院;

年份：2017

卷号：157

起止页码：166-173

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20172303731557);Scopus(收录号：2-s2.0-85020045960);WOS:【SCI-EXPANDED(收录号:WOS:000408597900020)】；

基金：This research was supported by the National Science Foundation of China (Nos. 51603211, 51503046, 51673107, 21604048), the MOST of China (2016YFA200800), the Guizhou Province Science and Technology Planning Project ([2015]2068), and the Scientific&Technological Innovation Talent Team of Guizhou Province (Qian Ke He Talent Team [2015]4008).

语种：英文

外文关键词：Zwitterionic phosphorylcholine polymer; Aggregation-induced emission; Critical micelle concentration; Fluorescent polymeric nanoparticles; Biocompatibility

摘要：Two novel zwitterionic phosphorylcholine polymers (MTP1 and MTP2) with aggregation-induced emission (AIE) feature were prepared through reversible addition fragmentation chain transfer polymerization between an AIE monomer with vinyl end group and a zwitterionic phosphorylcholine monomer. The synthesized copolymers were characterized and confirmed by H-1 NMR, FT-IR, and X-ray photoelectron spectra. By introduction of the zwitterionic phosphorylcholine component, the synthesized copolymers showed amphiphilic properties and tended to self-assemble into fluorescent polymeric nanoparticles (FPNs) in water. The dynamic light scattering results indicated the size distribution of the MTP1 FPNs was 345 +/- 22 nm, and that of the MTP2 FPN5 was 147 +/- 36 nm. The transmission electron microscopy results demonstrated spherical nanoparticle morphology for the FPNs. The high dispersibility of the FPNs in water was proved by the UV-vis absorption study with high transmittance of the solution. Fluorescent spectra of the prepared FPN5 revealed bright green fluorescence with high fluorescence quantum yield of 45% for MTP1 and 34% for MTP2. More importantly, the FPNs showed excellent particle stability with low critical micelle concentration of 0.008 mg mL-1 for MTP1 and0.007 mg mL(-1) for MTP2. The cytotoxicity evaluation confirmed high cytocompatibility of the prepared FPNs at different concentrations, and demonstrated excellent biocompatibility for cell imaging. In virtue of the high-performance MTP1 and MTP2 FPNs, including high water dispersion, good particle stability, and excellent cytocompatibility, this work would inspire more researches about high-performance biocompatible fluorescent polymers for biomedical application. (C) 2017 Elsevier B.V. All rights reserved.