文献类型：期刊文献

英文题名：Design, synthesis and anti-plant-bacterial (Xoc, Xac, Psa) activity of coumarins derivatives containing amide and sulfonamide moieties

作者：Bai, Song Zhang, Miaohe Wu, Rong Wan, Suran Chen, Lijun Tang, Shouying Wei, Xian Feng, Shuang Li, Miao

第一作者：柏松;Bai, Song

通信作者：Li, M[1]

机构：[1]Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China;[3]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn Minist Educ, Guiyang 550025, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China.

年份：2025

卷号：19

期号：1

外文期刊名：BMC CHEMISTRY

收录：;Scopus(收录号：2-s2.0-105010044679);WOS:【SCI-EXPANDED(收录号:WOS:001521878500006)】；

基金：Not applicable.

语种：英文

外文关键词：Coumarins; Amide; Sulfanilamide; Anti-plant-bacterial activity; Heterocyclic of natural products; Anti-Xoc activity; Anti-Xac activity; Anti-Psa activity

摘要：In this study, coumarin derivatives containing amide and sulfanilamide moieties were designed and synthesized, and their antibacterial activities were systematically evaluated. Among the synthesised compounds, compound A7 exhibited good inhibitory activity against Psa, with an EC50 value of 59.4 mg/L. Compound A2 presented the most potent antibacterial effect against Xoc, with an EC50 value of 43.2 mg/L. Compound A3 showed notable efficacy against Xac, with an EC50 value of 53.2 mg/L. Further mechanistic studies involving scanning electron microscopy (SEM) and extracellular conductivity (EC) measurements revealed that A2 induced morphological deformation and alterations in membrane permeability alterations in Xoc cells, suggesting a potential disruption of bacterial membrane integrity. Additionally, the structure-activity relationship (SAR) of these derivatives was elucidated using 3D-QSAR model, providing insights for further structural optimization. Furthermore, the chemical reactivity of potential bioactive compounds was evaluated using density functional theory (DFT).