文献类型：期刊文献

英文题名：Design, synthesis and antibacterial activity of quinazolinone derivatives containing glycosides

作者：Bai, Song Feng, Shuang Zhang, Wenjuan Mou, Honglan Tang, Shouying Zhou, Han Luo, Jianlin Wei, Xian Zhu, Yunying Wu, Rong Zhang, Miaohe

第一作者：Bai, Song;柏松

通信作者：Wu, R[1];Zhang, MH[2]

机构：[1]Guizhou Ind Polytech Coll, Guiyang, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang, Peoples R China;[3]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang, Peoples R China;[4]Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;[5]Guizhou Inst Technol, Sch Chem Engn, Guiyang, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;corresponding author), Guizhou Inst Technol, Sch Chem Engn, Guiyang, Peoples R China.|贵州理工学院化学工程学院;贵州理工学院;

年份：2024

卷号：768

期号：5

起止页码：72-88

外文期刊名：MOLECULAR CRYSTALS AND LIQUID CRYSTALS

收录：;EI(收录号：20240715534321);Scopus(收录号：2-s2.0-85184452999);WOS:【SCI-EXPANDED(收录号:WOS:001166731800001)】；

基金：No Statement Available

语种：英文

外文关键词：Antibacterial activity; changes in cell morphology; quinazolinone derivatives

摘要：A series of novel quinazolinone derivatives containing glycosides were designed and synthesized. The biological activities test found that this series of compounds had good antibacterial activities. Among all target compounds, compounds 1 and 15 showed good antibacterial activity in vitro against Pseudomonas syringae pv. actinidiae (Psa), with an EC50 value of 48.7 mg/L, 45.6 mg/L, respectively, which better than thiodiazole copper (54.6 mg/L) and zinc thiazole (49.2 mg/L). Compounds 15 and 23 showed good in vitro antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo) at a concentration of 100 mg/L, with inhibition rates of 79.3% and 77.1%, respectively, which better than thiodiazole copper (71.8%). In addition, compound 15 can cause significant deformation of cell surface. [GRAPHICS] .