文献类型：期刊文献

中文题名：β-环糊精-6-壳聚糖制备艾纳香生物碱微胶囊及稳定性研究

英文题名：Stability and preparation of alkaloid of Blumea balsamifera(L.) DC microcapsules by β-cyclodextrin-6-chitosan

作者：李小红 刘莹 李安 吴德智

第一作者：李小红

机构：[1]贵州理工学院

第一机构：贵州理工学院

年份：2017

卷号：0

期号：12

起止页码：251-257

中文期刊名：食品科技

外文期刊名：Food Science and Technology

收录：北大核心:【北大核心2014】；

基金：贵州省科学技术基金计划项目(黔科合LH字[2016]7094);创客空间项目(筑科合同[20151001]2-7号);贵州省大学生创新创业项目(201514440020);贵州省本科教学质量工程建设项目(黔高教发201533703)

语种：中文

中文关键词：艾纳香生物碱;微胶囊;Box-Behnken响应曲面实验;稳定性

外文关键词：alkaloid of Blumea balsamifera（L;） DC;microcapsules;Box-Behnken response surface methodology;stability

摘要：采用β-环糊精-6-壳聚糖(β-CS-CD)控制p H饱和水溶液法制备艾纳香生物碱微胶囊,以生物碱包埋率为指标,以芯壁比、搅拌时间和搅拌温度为考察因素,进行单因素及Box-Behnken响应曲面实验优化微胶囊配方。结果表明:艾纳香生物碱微胶囊最佳的制备工艺为芯壁比16.0、搅拌时间60 min和搅拌温度40℃,得出的生物碱包埋率为(61.36±0.31)%,经电镜法观察其形态规则,分布均匀。相比β-环糊精和壳聚糖制备的微胶囊,β-环糊精-6-壳聚糖的微胶囊稳定性更好,实验结果表明制备的微胶囊在高温、强光下包埋率稳定,高湿条件下包埋率有些下降,为微胶囊的进一步开发利用提供参考。
Alkaloid of Blumea balsamifera（L.） DC microcapsules were prepared by β-cyclodextrin-6-chitosan（β-CS-CD） saturated water solution method. Effects of ratio of wall to core, stirring time and stirring temperature were studied via the single factor methodologies, and then the optimal formula was determined by Box-Behnken response surface methodology. Study results showed that the optimal formula was ratio of wall to core 16.0, stirring time 60 min and stirring temperature 40 ℃. The rate of retention was（61.36±0.31）%. And the morphology was regular observed by electron microscope. Compared with the microcapsules prepared with β-cyclodextrin and chitosan, the microcapsules of β-cyclodextrin-6-chitosan had better stability. The results of stability test showed that the embedding rate was stable under high temperature and strong light, which was conductive to further study.