文献类型：期刊文献

英文题名：Synthesis and Biological Evaluation of Novel Coumarin Derivatives Bearing a Sulfonamide Moiety as Antiviral and Antibacterial Agent

作者：Bai, Song Liu, Lin Wu, Rong Tang, Shouyin Wan, Suran Wang, Fang Wei, Xian Chen, Lijun Xu, Shunyi Li, Miao

第一作者：柏松

通信作者：Bai, S[1];Li, M[1];Bai, S[2];Bai, S[3]|[1444086c12c707ddfe99e]柏松;

机构：[1]Guizhou Ind Polytech Coll, Guiyang Gui Orchard Ecol Environm Res Ctr, Guiyang 550008, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China;[3]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang Gui Orchard Ecol Environm Res Ctr, Guiyang 550008, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang Gui Orchard Ecol Environm Res Ctr, Guiyang 550008, Peoples R China;corresponding author), Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China;corresponding author), Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China.|贵州理工学院化学工程学院;贵州理工学院;

年份：2024

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001273820900001)】；

基金：The research is financially supported by the Science and Technology Planning Project of Guizhou Province (Grant No. Qian Ke He Ji Chu ZK[2022]Zhong Dian 025), the High School Science and Technology Talent Support Project of Guizhou Province, China (Grant No. Qian JiaoHe KY Zi [2021]037), the Guizhou Industry Polytechnic College Science and Technology Innovation Team Project (Grant No. 2023CX-TD03), the High-Level Talent Initial Funding of Guizhou Industry Polytechnic College (Grant No. 2023-RC-01), The Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University (Grant No. Qian Jiao Ji [2022]433), the Academic New Seedling Cultivation and Exploration and Innovation Project of Guizhou Institute of Technology(No. GZLGXM-20), Guizhou Industry Polytechnic College Faculty-Level Research Project (Grant No. 2023ZK10 and Grant No. 2023ZK11).

语种：英文

外文关键词：coumarin derivatives; antiviral activity; antibacterial activity; TMV; CMV; PVY; Xoo; Psa

摘要：Twenty novel 4-bromocoumarin derivatives bearing a sulfonamide moiety were designed and synthesized. Their antiviral and antibacterial activities were systematically evaluated. The test results show that all the target compounds possess moderate to excellent antiviral and antibacterial activities. Among all target compounds, one compound exhibited good antiviral activity against TMV, CMV, and PVY, which is superior to ribavirin. Moreover, two target compounds exhibited good in vitro antibacterial activity against Psa , with an EC50 value of 44.9 mg/L and 49.3 mg/L, respectively, which were better than thiodiazole copper and zinc thiazole, with an EC50 value of 56.3 mg/L and 50.2 mg/L, respectively. The results provide insights for the development of multifunctional pesticides.