文献类型：期刊文献

中文题名：PLA/PCL/HL560生物基医用复合可降解材料的制备与性能

英文题名：Fabrication and Performance of PLA/PCL/HL560 Bio-based Medical Biodegradable Composite

作者：肖世伟 李亚楠 李杨

第一作者：肖世伟

机构：[1]贵州省人民医院,贵阳550002;[2]贵州中医药大学药用矿物与资源开发研究中心,贵阳550025;[3]贵州理工学院材料与能源工程学院,贵阳550003

第一机构：贵州省人民医院,贵阳550002

年份：2022

卷号：50

期号：1

起止页码：14-20

中文期刊名：工程塑料应用

外文期刊名：Engineering Plastics Application

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：贵州省卫生健康委科学技术基金(gzwjkj2019-1-129);贵州中医药大学博士启动基金(贵中医博士启动[2020]80号)。

语种：中文

中文关键词：聚乳酸;聚己内酯;亲水剂HL560;力学性能;降解行为;亲水性

外文关键词：polylactic acid;polycaprolactone;hydrophilic agent HL560;mechanical property;degradation behavior;hydrophilicity

摘要：以可降解亲水剂HL560和聚己内酯(PCL)对聚乳酸(PLA)进行改性处理,研究了添加HL560前后PLA性能的变化情况,以及在HL560作用下PCL含量的变化对改性材料力学性能、加工性能、热行为、亲水性和降解行为的影响。结果表明,添加质量分数15%PCL和5%HL560的改性材料弯曲弹性模量比纯PLA提高46.1%,添加质量分数30%PCL和5%HL560的改性材料断裂伸长率和缺口冲击强度分别比纯PLA提高240.7%和250%,添加质量分数20%PCL和5%HL560的改性材料水接触角比纯PLA降低21.6°。碱溶液降解行为结果表明,HL560改性PLA材料的降解速率大幅增加,在碱溶液中降解8 d后质量损失率为62.2%。添加PCL后,改性材料的降解程度下降,但降解速率均高于纯PLA,改性材料内部的崩解降解优先针对于PCL。PLA和HL560的共混会抑制HL560的结晶,促进PLA的结晶。引入PCL后,PLA相的冷结晶温度向高温方向偏移,结晶被抑制。PLA/PCL/HL560改性材料的制备为其在医用领域如输尿管支架的应用提供了基础。
Polylactic acid(PLA)was modified with hydrophilic agent HL560 and polycaprolactone(PCL).The changes of performances of PLA before and after adding HL560 were studied and the influences of PCL content variations on mechanical properties,processing properties,thermal behavior,hydrophilicity and degradation behavior were explored.The results show that,compared with pure PLA,the flexural modulus of modified material with 15wt%PCL and 5wt%HL560 increases by 46.1%,the elongation at break and notched impact strength of the modified material with 30wt%PCL and 5wt%HL560 increases by 240.7%and 250%,respectively,and the water contact angle of the modified material with 20wt%PCL and 5wt%HL560 is decreased by 21.6°.The degradation behavior of alkaline solution shows that the degradation rate of HL560 modified PLA material increases greatly,and the weight loss ratio is 62.2%after 8 days of degradation.After adding PCL,the degree of degradation of the modified material is reduced,but the degradation rates are all significantly higher than that of pure PLA.The internal disintegration and degradation of the modified material is prioritized for PCL.The blending of PLA and HL560 inhibits the crystallization of HL560 and promote the crystallization of PLA.After the introduction of PCL,the cool crystallization temperature of the PLA phase shifts to the high temperature direction,and the crystallization is suppressed.The fabrication of PLA/PCL/HL560 modified materials provides a foundation for its application in medical fields such as ureteral stents.