文献类型：期刊文献

英文题名：Investigation of antibacterial activity and mechanism of action: Design and synthesis of coumarin derivatives containing sulfonamide groups

作者：Bai, Song Zhang, Miaohe Li, Miao Wan, Suran Wang, Fang Tang, Shouyin Chen, Lijun Wei, Xian Wu, Rong

第一作者：Bai, Song

通信作者：Wu, R[1]

机构：[1]Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China;[3]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China.

年份：2025

卷号：67

外文期刊名：PHYTOCHEMISTRY LETTERS

收录：;Scopus(收录号：2-s2.0-105000493401);WOS:【SCI-EXPANDED(收录号:WOS:001456729500001)】；

基金：The authors gratefully acknowledge the Science and Technology Planning Project of Guizhou Province (Grant No. Qian Ke He Ji Chu ZK [2022] Zhong Dian 025) ; the High School Science and Technology Talent Support Project of Guizhou Province, China (Grant No. Qian Jiao He KY Zi [2021]037) ; the High-Level Talent Initial Funding of Guizhou Industry Polytechnic College (Grant No. 2023-RC-01) ; the Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University (Grant No. Qian Jiao Ji [2022]433) ; the Guizhou Provincial Department of Education Youth Science and Technology Talent Growth Project (Grant No. Qian Jiao Ji [2024]293 Hao) ; the Guizhou Industry Polytechnic College Science and Technology Innovation Team Project (Grant No. 2023CXTD03) ; the Guizhou Industry Polytechnic College Faculty-level Research Project (Grant No. 2023ZK10 & Grant No. 2023ZK11) ; the Young Science and Technology Talents Development Program of Education Department of Guizhou Province (Grant No. Qian Jiao He KY Zi [2022]346 Hao) ; and the Academic New Seedling Cultivation and Exploration and Innovation Project of Guizhou Institute of Technology (Grant No. GZLGXM-20) ; Guizhou Industry Polytechnic College Faculty-level Research Project (grant no. 2024zk18 & 2024zk19) . We thank LetPub (http:// www.letpub.com .cn) for its linguistic assistance during the preparation of this manuscript.

语种：英文

外文关键词：Coumarin derivatives; Biological activity; Antibacterial activity; Mechanism of action

摘要：In this innovative study, we combined coumarin with a sulfonamide group and synthesized a series of coumarin derivatives. In vitro antibacterial activity tests, these derivatives demonstrated antibacterial potential, especially compound 27, whose antibacterial effect was particularly remarkable. Our experimental results revealed that compound 27 enhanced bacterial cell membrane permeability by disrupting the cell membrane of Xanthomonas oryzae pv. oryzicola, thereby effectively inhibiting its growth and reproduction. This not only provides insights into our understanding of the mechanism of action of compound 27, but also represents a breakthrough in the development of novel antibacterial agents, offering unlimited possibilities for the future of agriculture and medicine.