文献类型：期刊文献

英文题名：Advanced polymer composites and polymer hybrids for cartilage tissue engineering

作者：Liu, Shan Hu, Xiao He, Min Liu, Wei Zhou, Dengfeng Li, Yang Qin, Shuhao

通信作者：Liu, S[1];Qin, SH[2]

机构：[1]Guizhou Inst Technol, Coll Mat & Energy Engn, Guiyang 550003, Peoples R China;[2]Guizhou Prov Peoples Hosp, Dept Neurol, Guiyang, Peoples R China;[3]Guizhou Univ, Coll Mat & Met, Guiyang 550025, Peoples R China

第一机构：贵州理工学院

通信机构：corresponding author), Guizhou Inst Technol, Coll Mat & Energy Engn, Guiyang 550003, Peoples R China;corresponding author), Guizhou Univ, Coll Mat & Met, Guiyang 550025, Peoples R China.|贵州理工学院;

年份：2024

外文期刊名：POLYMER COMPOSITES

收录：;EI(收录号：20242316212975);Scopus(收录号：2-s2.0-85195136420);WOS:【SCI-EXPANDED(收录号:WOS:001238365500001)】；

基金：The authors acknowledge financial support from the National Natural Science Foundation of China (Grant No. 52163011, 82060228), Science and Technology Project of Guizhou Province (QianKeHe Zhicheng [2023] General 146 : QianKeHe FuQi [2023] 001 : QianKeHe ZhongYinDi [2023] 035).

语种：英文

外文关键词：biolubricant; cartilage; drug delivery; polymer scaffold; sustained release; tissue engineering

摘要：The repair and regeneration of cartilage is a challenge for scientists and clinical surgery. Achieving cell adhesion and regeneration, anti-inflammatory, lubrication, targeted drug delivery and controlled release simultaneously in cartilage treatment are the goals of researchers. Polymer composites and hybrids have the potential to realize above functions in cartilage tissue engineering. This review refers to cartilage injuries, current clinical techniques, and their benefits and limitations, focusing on the most relevant and state of art of advanced polymers for cartilage tissue engineering. The frontier applications of multifunctional polymer composites and hybrids in cartilage tissue engineering are discussed in depth, including polymer scaffold, polymer bio-lubricant, and zwitterionic polymer for drug delivery and sustained drug release. A summary of comprehensive properties of polymers such as processability, mechanical properties, biocompatibility, biodegradability, hydrophilicity, cytotoxicity, etc., and their mechanisms are analyzed. Furthermore, some key challenges and outstanding concerns on polymer-based materials for cartilage tissue engineering are presented followed by future perspectives.