文献类型：期刊文献

英文题名：Protein-Derived Chelating Peptides: Preparation, Conformational Relationships, and Biological Activities

作者：Guan, Huiwen Yan, Chao Zhu, Xuchun Wang, Xuteng Liu, Mengying Huang, Mingzheng Zhou, Linyi Wang, Zhongjiang Liu, Hongzhi

第一作者：Guan, Huiwen

通信作者：Liu, HZ[1];Liu, HZ[2]

机构：[1]Beijing Technol & Business Univ, Key Lab Geriatr Nutr & Hlth, Haidian 100080, Peoples R China;[2]Guizhou Inst Technol, Guizhou 550003, Peoples R China;[3]Northeast Agr Univ, Sch Food Sci, Harbin 150030, Peoples R China

第一机构：Beijing Technol & Business Univ, Key Lab Geriatr Nutr & Hlth, Haidian 100080, Peoples R China

通信机构：corresponding author), Beijing Technol & Business Univ, Key Lab Geriatr Nutr & Hlth, Haidian 100080, Peoples R China;corresponding author), Guizhou Inst Technol, Guizhou 550003, Peoples R China.|贵州理工学院;

年份：2025

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001568205400001)】；

基金：The authors gratefully acknowledge the financial support from Guizhou Provincial Science and Technology Department (KXJZ[2024]021) and Beijing High-level Talent Project (ID19008024075) for financial support.

语种：英文

外文关键词：metal ion-chelating activepeptide; chelationmechanism; conformational relationship; biologicalactivity

摘要：Metal ions play a vital role in the health of the modern human body, but deficiencies in mineral elements have created health risks worldwide. However, mineral supplements currently available on the market are very limited due to poor solubility, low bioavailability, and the possibility of adverse effects on the gastrointestinal tract. In contrast, protein-derived metal-chelating peptides have received a lot of attention because of their stability, safety, and very high bioavailability. The present paper discusses the protein sources of protein-derived metal-chelating peptides as well as peptide preparation, isolation and purification, and chelating peptide preparation. Furthermore, it describes the chelating mechanism of the chelating peptides and their conformational relationships. Moreover, the protein-derived metal ion-chelating peptides provide additional benefits by enhancing the absorption of minerals and providing antioxidant and immunomodulatory bioactivities.