文献类型：期刊文献

英文题名：Antibacterial Activity and Mechanism of Action of New Benzylamine-Containing Coumarin Derivatives

作者：Bai, S. Zhang, M. Li, M. Wan, S. Wang, F. Tang, S. Wei, X. Feng, S. Wu, R.

第一作者：Bai, S.;柏松

通信作者：Wu, R[1]

机构：[1]Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China;[3]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Minist Educ, Guiyang 550025, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China.

年份：2024

卷号：94

期号：12

起止页码：3436-3447

外文期刊名：RUSSIAN JOURNAL OF GENERAL CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85217692753);WOS:【SCI-EXPANDED(收录号:WOS:001408603600019)】；

基金：The authors gratefully acknowledge the High School Science and Technology Talent Support Project of Guizhou Province, China (grant no. Qian Jiao He KY Zi [2021]037), Science and Technology Planning Project of Guizhou Province (grant no. Qian Ke He Ji Chu ZK [2022]Zhong Dian 025), High- Level Talent Initial Funding of Guizhou Industry Polytechnic College (grant no. 2023-RC-01), the Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University (grant no. Qian Jiao Ji [2022]433), Guizhou Provincial Department of Education Youth Science and Technology Talent Growth Project (grant no. Qian Jiao Ji [2024]293 Hao), Guizhou Industry Polytechnic College Science and Technology Innovation Team Project (grant no. 2023CXTD03), Guizhou Industry Polytechnic College Faculty-level Research Project (grant no. 2023ZK10 & grant no. 2023ZK11), Guizhou Industry Polytechnic College Faculty-level Research Project (grant no. 2024zk18 & 2024zk19), the Young Science and Technology Talents Development Program of Education Department of Guizhou Province (grant no. Qian Jiao He KY Zi [2022]346 Hao), the academic new seedling cultivation and exploration and innovation project of Guizhou Institute of Technology (no. GZLGXM-20).

语种：英文

外文关键词：coumarin derivatives; antibacterial activity; changes in cell morphology

摘要：AbstractA series of novel coumarin derivatives was successfully synthesized by combining the coumarin skeleton with a benzylamine moiety. These derivatives showed better antibacterial activities in vitro tests, especially compound, which was particularly effective. The mechanism of the antibacterial action of compound was thoroughly investigated, and the experimental results revealed that compound was able to increase the permeability of bacterial cell membranes, leading to the disruption of Xoc membranes and effectively inhibiting bacterial growth and reproduction. This finding not only elucidates the antibacterial mechanism of compound, but also provides an important scientific basis for the development of new antibacterial agents in the future.