文献类型：期刊文献

英文题名：Ring-opening crosslinking PEGylation of an AIE epoxy monomer towards biocompatible fluorescent nanoparticles

作者：Ma, Chunping Xie, Gaoyi Zhang, Xiqi Yang, Liutao Li, Yang Liu, Hongliang Wang, Ke Wei, Yen

第一作者：马春平

通信作者：Zhang, XQ[1];Zhang, XQ[2];Wei, Y[2];Zhang, XQ[3];Wei, Y[3];Wang, K[4]

机构：[1]Guizhou Inst Technol, Coll Mat & Met Engn, Guiyang 550003, Peoples R China;[2]Chinese Acad Sci, Lab Bioinspired Smart Interface Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China;[3]Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China;[4]Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China;[5]Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

第一机构：贵州理工学院材料与冶金工程学院

通信机构：corresponding author), Chinese Acad Sci, Lab Bioinspired Smart Interface Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China;corresponding author), Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China;corresponding author), Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China;corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.

年份：2016

卷号：4

期号：48

起止页码：8009-8015

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20165003123654);Scopus(收录号：2-s2.0-85002648459);WOS:【SCI-EXPANDED(收录号:WOS:000391778200024)】；

基金：This research was supported by the MOST of China (2016YFA200800), the National Science Foundation of China (No. 51603211, 51673107, 51673107, 21604048), the Guizhou Province Science and Technology Planning Project ([2015]2068), and the Research Project for High-level Talents of Guizhou Institute of Technology (XJGC201503).

语种：英文

外文关键词：Biocompatibility - Critical micelle concentration - Crosslinking - Gel permeation chromatography - High resolution transmission electron microscopy - Light scattering - Light transmission - Medical applications - Micelles - Monomers - Nanoparticles - Nuclear magnetic resonance spectroscopy - Photoelectron spectroscopy - Polymers - Rings (components) - Sols - X ray photoelectron spectroscopy

摘要：Here we report the ring-opening crosslinking PEGylation of an AIE epoxy monomer and a 4-arm PEG-amine to prepare a new cross-linked fluorescent polymer (PEG-EP3). When PEG-EP3 was dispersed in aqueous solution, the AIE components formed the hydrophobic cores and the PEG parts covered the surfaces, resulting in fluorescent polymeric nanoparticles (FPNs) with good dispersibility. PEG-EP3 and the resulting FPNs were characterized by gel permeation chromatography, H-1 NMR spectroscopy, FT-IR spectroscopy, X-ray photoelectron spectroscopy, dynamic light scattering, transmission electron microscopy, UV-Visible absorption and fluorescence spectra. The results confirmed the successful synthesis of PEG-EP3, which showed high water dispersibility with a size distribution of 249 +/- 1 nm, intense yellow-green fluorescence in aqueous solution with a fluorescence quantum yield of 35%, and a low critical micelle concentration (CMC) of 0.039 mg mL(-1). The cell uptake behaviour and cell imaging of the PEG-EP3 FPNs proved their high biocompatibility for biomedical applications. Owing to their excellent biocompatibility by the introduction of PEG as the main component, good colloidal stability with low CMC, and high fluorescence stability, the strategy in this work would provide a new approach to prepare novel biocompatible and robust cross-linked FPNs for biomedical applications.