文献类型：期刊文献

英文题名：Synthesis, Bioactive Evaluation, and Preliminary Antibacterial Mechanism Study of Novel Ferulic Acid Derivatives

作者：Bai, Song Li, Miao Wu, Rong Tang, Shouying Wang, Fang Chen, Lijun Wei, Xian Feng, Shuang Zhang, Miaohe Wan, Suran

第一作者：柏松

通信作者：Bai, S[1];Bai, S[2];Bai, S[3]|[14440625ef7c60d4893dd]柏松;[144409b159ce598c03843]柏松;

机构：[1]Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China;[3]Guizhou Univ, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;corresponding author), Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China;corresponding author), Guizhou Univ, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China.|贵州理工学院化学工程学院;贵州理工学院;

年份：2025

卷号：51

期号：4

起止页码：1529-1546

外文期刊名：RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

收录：;Scopus(收录号：2-s2.0-105012034482);WOS:【SCI-EXPANDED(收录号:WOS:001539307600019)】；

基金：The authors gratefully acknowledge the financial support from the Science and Technology Planning Project of Guizhou Province (grant no. Qian Ke He Ji Chu ZK [2022] Zhong Dian 025), the High School Science and Technology Talent Support Project of Guizhou Province, China (grant no. Qian Jiao He KY Zi [2021] 037), the High-Level Talent Initial Funding of Guizhou Industry Polytechnic College (grant no. 2023-RC-01), the Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University (grant no. Qian Jiao Ji [2022] 433), the Youth Science and Technology Talent Growth Project of the Guizhou Provincial Department of Education (grant no. Qian Jiao Ji [2024] 293 Hao), the Guizhou Industry Polytechnic College Science and Technology Innovation Team Project (grant no. 2023CXTD03), the Faculty-level Research Projects of Guizhou Industry Polytechnic College (grant nos. 2023ZK10 and 2023ZK11), the Young Science and Technology Talents Development Program of the Education Department of Guizhou Province (grant no. Qian Jiao He KY Zi [2022] 346 Hao), and the Academic Seedling Cultivation and Innovation Exploration Project of Guizhou Institute of Technology (grant no. GZLGXM-20).

语种：英文

外文关键词：ferulic acid derivatives; synthesis; antibacterial activity; structure-activity relationship; antibacterial mechanism

摘要：Objective: The aim of this study was to design and synthesize a series of ferulic acid derivatives containing amide moieties and to evaluate their activity against plant pathogenic bacteria. Methods: The structures of the synthesized compounds (IIIa-IIIy) were thoroughly characterized using 1H, 13C NMR, and HR-MS techniques. The antibacterial activity of the target compounds against Xanthomonas oryzae pv. oryzicola (Xoc), Pseudomonas syringae pv. actinidiae (Psa), and Xanthomonas axonopodis pv. citri (Xac) was evaluated in vitro using the turbidity method. Results and Discussion: The bioassay results indicated that some of the target compounds exhibited enhanced inhibitory activity against the tested phytopathogenic bacteria. In particular, compound (IIId) demonstrated potent activity against Xoc, with an EC50 value of 24.4 mu g/mL, which is more than three times more active than the reference agent thiodiazole copper (EC50 = 86.7 mu g/mL). Additionally, compound (IIId) showed significant antibacterial activity against Psa, with an EC50 of 55.4 mu g/mL, outperforming the reference compound zinc thiazole (EC50 = 102.2 mu g/mL). Mechanistic studies suggested that compound (IIId) exerts its antibacterial effect by increasing bacterial membrane permeability, reducing exopolysaccharide content, and inducing morphological alterations in bacterial cells. In vitro cytotoxicity assays indicated that compound (IIId) is essentially non-toxic to mammalian cells. Conclusions: Compound (IIId) exhibits promising potential as a lead compound for the development of more effective agricultural antibacterial agents to control Xoc in the future.