文献类型：期刊文献

英文题名：Three new polyhydroxy-chlorinated dibenzo-α-pyrones isolated from Helicosporium sexuale LZ15

作者：Zhang, Li-Juan Ma, Xiao-Yan Han, Mei-Yan Zheng, De-Ge Ma, Jian Xiao, Xing-Juan Jayawardena, Ruvishika S. Mapook, Ausana Hyde, Kevin D. Lu, Yong-Zhong

第一作者：Zhang, Li-Juan;张丽娟

通信作者：Lu, YZ[1]

机构：[1]Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang 550025, Guizhou, Peoples R China;[2]Guizhou Acad Agr Sci, Guizhou Key Lab Agr Microbiol, Guiyang 550009, Peoples R China;[3]Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand;[4]Mae Fah Luang Univ, Ctr Excellence Fungal Res, Chiang Rai 57100, Thailand;[5]Chiang Mai Univ, Excellence Ctr Microbial Divers & Sustainable Util, Chiang Mai 50200, Thailand;[6]Qujing Normal Univ, Coll Biol & Food Engn, Ctr Yunnan Plateau Biol Resources Protect & Utiliz, Qujing 655099, Peoples R China; Qujing Normal Univ, Coll Biol & Food Engn, Yunnan Int Joint Lab Fungal Sustainable Utilizat S, Qujing 655099, Peoples R China;[7]Guizhou Ind Polytech Coll, Guiyang 550008, Guizhou, Peoples R China

第一机构：贵州理工学院食品药品制造工程学院

通信机构：corresponding author), Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang 550025, Guizhou, Peoples R China.|贵州理工学院食品药品制造工程学院;贵州理工学院;

年份：2026

卷号：189

外文期刊名：FITOTERAPIA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001677887000001)】；

基金：This work was financed by the National Natural Science Foundation of China (NSFC 32360011) , the Science and Technology Foundation of Guizhou Province (Qian Ke He Pingtai ZSYS [2025] 029) , Guizhou Provincial Science and Technology Department (KXJZ [2024] 021) and Start-up Project for Guizhou Institute of Technology High-Level Talent Research (2023GCC069) . Li-Juan Zhang thanks Mae Fah Luang Uni-versity for granting her the tuition fee scholarship.

语种：英文

外文关键词：Helicosporium sexuale; Dibenzo-alpha-pyrones; Polyhydroxy-chlorinated fused isocoumarin; Cytotoxicity

摘要：Three new chlorine-substituted dibenzo-alpha-pyrone derivatives, helicochlorins A-C (1-3), together with three known congeners (4-6), were isolated from fermented rolled oats culture of Helicosporium sexuale LZ15. Helicochlorins A-C (1-3) share a polyhydroxy-chlorinated fused isocoumarin framework, characterized primarily by a chlorine substituent on the fused-ring system. The structures of the new compounds were unambiguously elucidated by comprehensive spectroscopic analyses (1D and 2D NMR, HRESIMS) and further confirmed through NOE correlations and ECD calculations. In addition, the crystal structure of compound 4 was determined for the first time. The cytotoxicity evaluation revealed that compound 2 exhibited weak activity against A549 cells, compound 5 showed weak activity against HepG2 cells, while compound 4 demonstrated weak cytotoxicity toward both A549 and HepG2 cell lines.