文献类型：期刊文献

英文题名：Bioactive Isocoumarin Derivatives from the Endophytic Fungus Paraconiothyrium bonneyae NS16 of Pteris multifida

作者：Zhang, Lijuan Zhang, Jingyi Ma, Xiaoyan Han, Meiyan Zheng, Dege Xiao, Xingjuan Lu, Yongzhong

第一作者：Zhang, Lijuan;张丽娟

通信作者：Lu, YZ[1];Lu, YZ[2]

机构：[1]Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang, Peoples R China;[2]Guizhou Acad Agr Sci, Guizhou Key Lab Agr Microbiol, Guiyang, Peoples R China;[3]Mae Fah Luang Univ, Sch Sci, Chiang Rai, Thailand;[4]Mae Fah Luang Univ, Ctr Excellence Fungal Res, Chiang Rai, Thailand;[5]Chiang Mai Univ, Excellence Ctr Microbial Divers & Sustainable Util, Chiang Mai, Thailand;[6]Qujing Normal Univ, Ctr Yunnan Plateau Biol Resources Protect & Utiliz, Qujing, Peoples R China;[7]Qujing Normal Univ, Coll Biol & Food Engn, Yunnan Int Joint Lab Fungal Sustainable Utilizat S, Qujing, Peoples R China

第一机构：贵州理工学院食品药品制造工程学院

通信机构：corresponding author), Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang, Peoples R China;corresponding author), Guizhou Acad Agr Sci, Guizhou Key Lab Agr Microbiol, Guiyang, Peoples R China.|贵州理工学院食品药品制造工程学院;贵州理工学院;

年份：2026

卷号：23

期号：2

外文期刊名：CHEMISTRY & BIODIVERSITY

收录：;Scopus(收录号：2-s2.0-105029761944);WOS:【SCI-EXPANDED(收录号:WOS:001707425200007)】；

基金：This work was financially supported by the National Natural Science Foundation of China (NSFC 32360011), the Science and Technology Foundation of Guizhou Province (Qian Ke He Pingtai ZSYS[2025]029), Guizhou Provincial Science and Technology Department (KXJZ[2024]021) and Guizhou Institute of Technology High-Level Talent Research Start-up Project (2023GCC069) and Youth Science and Technology Talent Development Project from Guizhou Provincial Department of Education [QJHKYZ (2022) 345].

语种：英文

外文关键词：antioxidant activity; antidiabetic activity; Paraconiothyrium bonneyae; polyketide; Pteris multifida

摘要：An endophytic fungus isolated from the roots of Pteris multifida was identified as Paraconiothyrium bonneyae NS16 based on morphology combined with multigene phylogenetic analysis (ITS, LSU, SSU, TUB2, and TEF1-alpha). Rice-fermented cultures of P. bonneyae NS16 yielded three new isocoumarin derivatives (1-3) together with three known compounds (4-6). Their chemical structures were elucidated by high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance, and single-crystal X-ray diffraction. In bioactivity evaluations, compounds 1-6 exhibited notable antioxidant activity, with oxygen radical absorbance capacity values ranging from 0.27 +/- 0.02 to 4.94 +/- 0.17 (& micro;mol TE)/& micro;mol. In addition, compound 1 showed inhibitory activity against alpha-glucosidase and protein tyrosine phosphatase 1B, with 50% inhibitory concentration values of 353.5 and 27.15 & micro;mol/L, respectively. These results highlight P. bonneyae as a productive source of bioactive isocoumarins and support their potential as antioxidant and antidiabetic leads.