文献类型：期刊文献

英文题名：Biocompatible fluorescent polymers from PEGylation of an aggregation-induced emission dye

作者：Ma, Chunping Xie, Gaoyi Zhang, Xiqi Yang, Liutao Li, Yang Liu, Hongliang Wang, Ke Wei, Yen

第一作者：马春平

通信作者：Zhang, XQ[1];Wei, Y[2];Wei, Y[3];Wang, K[4]

机构：[1]Guizhou Inst Technol, Coll Mat & Met Engn, Guiyang 550003, Peoples R China;[2]Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Bioinspired Mat & Interface Sci, Beijing 100190, Peoples R China;[3]Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China;[4]Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China;[5]Guizhou Inst Technol, Coll Chem Engn, Guiyang 550003, Peoples R China;[6]Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

第一机构：贵州理工学院材料与冶金工程学院

通信机构：corresponding author), Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Bioinspired Mat & Interface Sci, Beijing 100190, Peoples R China;corresponding author), Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China;corresponding author), Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China;corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China.

年份：2017

卷号：139

起止页码：672-680

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：20170203228164);Scopus(收录号：2-s2.0-85008392507);WOS:【SCI-EXPANDED(收录号:WOS:000394063800080)】；

基金：This research was supported by the National Science Foundation of China (Nos. 51503046, 51603211, 51673107, 21604048, 51503214), the MOST of China (2016YFA200800), the Guizhou Province Science and Technology Planning Project ([2015]2068), and the Scientific & Technological Innovation Talent Team of Guizhou Province (Qian Ke He Talent Team [2015]4008).

语种：英文

外文关键词：Aggregation-induced emission; Fluorescent polymeric nanoparticles; Particle stability; Photostability; Biocompatibility; Cell imaging

摘要：Novel aggregation-induced emission (AIE) polymers (NS1 and NS2) were prepared through reversible addition fragmentation chain transfer polymerization of poly(ethylene glycol) monomethyl ether methacylate and a new AIE monomer with a vinyl group. The NS1 and NS2 copolymers were characterized by gel permeation chromatography, H-1 NMR spectroscopy, FT-IR spectroscopy, X-ray photoelectron spectroscopy, which proved their successful syntheses. Such amphiphilic copolymers could self assemble into fluorescent polymeric nanoparticles (FPNs) in water with good dispersibility, which were spherical in shape. The prepared FPNs of NS1 had a size range of 50-150 nm, strong green fluorescence in aqueous solution With fluorescence quantum yield of 31%, and low critical micelle concentration (CMC) of 0.030 mg mL(-1). The NS2 FPNs exhibited size range of 200-300 nm, intense green fluorescence with quantum yield of 38%, and CMC of 0.037 mg mL(-1). These FPNs were demonstrated highly biocompatible for cell imaging. By virtue of excellent biocompatibility via PEG modification, good particle stability with low CMC, and AIE fluorescent polymers with high photostability, the FPNs constructed in this work showed obvious advantages. This strategy should inspire new approaches to prepare novel biocompatible AIE fluorescent polymers for biomedical application. (C) 2017 Elsevier Ltd. All rights reserved.