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基于节点增强设计的水凝胶晶格DLP打印研究    

Research on Hydrogel Lattice DLP Printing Based on Node-enhanced Design

文献类型:期刊文献

中文题名:基于节点增强设计的水凝胶晶格DLP打印研究

英文题名:Research on Hydrogel Lattice DLP Printing Based on Node-enhanced Design

作者:石文海 李屹 李家春 邹中妃 史方涛

第一作者:石文海

机构:[1]贵州大学机械工程学院,贵州贵阳550025;[2]贵州理工学院机械工程学院,贵州贵阳550025

第一机构:贵州大学机械工程学院,贵州贵阳550025

年份:2025

期号:4

起止页码:65-70

中文期刊名:电加工与模具

外文期刊名:Electromachining & Mould

收录:;北大核心:【北大核心2023】;

基金:贵州省科技厅科技支撑计划项目(2022196);贵州省科技厅条件平台项目(2023010);贵州省科技厅-贵州大学联合基金项目(2024020)。

语种:中文

中文关键词:DLP打印;晶格结构;节点增强设计;GelMA水凝胶

外文关键词:DLP printing;lattice structure;node-enhanced design;GelMA hydrogel

摘要:晶格结构因其可调的孔隙率、孔径及强度,在组织工程中备受关注。针对生物相容性好且模量低的甲基丙烯酰化明胶(GelMA)水凝胶,使用数字光处理(DLP)技术打印高孔隙率晶格时,剥离行为易导致结构损伤和断裂,故提出一种节点增强晶格结构的方法,通过数值模拟分析节点尺寸对晶格抗剥离性能的影响。仿真结果表明,节点增强设计能改善应力分布,减小应力集中,显著提高晶格的抗剥离能力。实验结果验证了该方法能实现孔隙率达到90%的GelMA水凝胶晶格结构的光固化成形,拓宽了GelMA晶格孔隙率的打印范围;GelMA晶格的模量可在0.7~40.4 kPa调节,具备更广泛的模量调节范围,为水凝胶晶格结构的增强设计与打印提供了技术参考。
Lattice structures have garnered significant attention in tissue engineering due to their tunable porosity,pore size,and strength.However,when using gelatin methacryloyl(GelMA)hydrogel,which is biocompatible and low-modulus,delamination during digital light processing(DLP)printing of high-porosity lattices can lead to structural damage and failure.To address this issue,a node-enhanced lattice design method was proposed.The impact of node size on the delamination resistance of the lattice was analyzed through numerical simulations.The simulation results showed that the node-enhanced design improved stress distribution,reduced stress concentration,and significantly increased the delamination resistance of the lattice.Experimental results confirmed that this method enabled the successful photopolymerization of GelMA lattices with 90%porosity,thus expanding the printable porosity range of GelMA lattices.Additionally,the modulus of the GelMA lattice can be adjusted between 0.7 and 40.4 kPa,providing a wider range of modulus tunability.The proposed design method offers valuable technical insights for the enhanced design and printing of hydrogel lattice structures.

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