文献类型：期刊文献

英文题名：A biocompatible cross-linked fluorescent polymer prepared via ring-opening PEGylation of 4-arm PEG-amine, itaconic anhydride, and an AIE monomer

作者：Ma, Chunping Zhang, Xiqi Wang, Ke Zhang, Xiaoyong Zhou, Yahong Liu, Hongliang Wei, Yen

第一作者：马春平

通信作者：Ma, CP[1]|[144404c59386af0196f94]马春平;

机构：[1]Guizhou Inst Technol, Col Mat & Met Engn, Guiyang 550003, Peoples R China;[2]Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China;[3]Tsinghua Univ, Tsinghua Ctr Frontier Polymer Res, Beijing 100084, Peoples R China;[4]Chinese Acad Sci, Tech Inst Phys & Chem, Lab Bioinspired Smart Interface Sci, Beijing 100190, Peoples R China

第一机构：贵州理工学院材料与冶金工程学院

通信机构：corresponding author), Guizhou Inst Technol, Col Mat & Met Engn, Guiyang 550003, Peoples R China.|贵州理工学院材料与冶金工程学院;贵州理工学院;

年份：2015

卷号：6

期号：19

起止页码：3634-3640

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20152000849447);Scopus(收录号：2-s2.0-84929179788);WOS:【SCI-EXPANDED(收录号:WOS:000354198000009)】；

基金：This research was supported by the National Science Foundation of China (no. 21134004, 21201108, and 51363016), National 973 Project (no. 2011CB935700), and China Postdoctoral Science Foundation (2012M520243, 2013T60100).

语种：英文

外文关键词：Biocompatibility - Crosslinking - Fluorescence - Gel permeation chromatography - High resolution transmission electron microscopy - Light scattering - Medical applications - Monomers - Nanoparticles - Nuclear magnetic resonance spectroscopy - Polyethylene glycols - Polyethylene oxides - X ray photoelectron spectroscopy

摘要：A novel cross-linked fluorescent polymer (PhE-ITA-PEG) was prepared through radical polymerization between an aggregation-induced emission (AIE) monomer and itaconic anhydride, and subsequent ring-opening PEGylation with 4-arm PEG-amine. The resulting fluorescent polymer could self-assemble to form polymeric nanoparticles in aqueous solution with hydrophilic PEG groups covered at the surfaces and the hydrophobic AIE components aggregated into the cores. The successful synthesis of the obtained PhE-ITA-PEG copolymer was fully characterized and confirmed by a series of techniques including gel permeation chromatography, H-1 NMR spectroscopy, FT-IR spectroscopy, and X-ray photoelectron spectroscopy. Meanwhile, transmission electron microscopy and dynamic light scattering have been carried out to determine the morphology and distribution of these polymeric nanoparticles. UV-visible absorption spectra and fluorescence spectra have also been investigated to study their optical performances. Finally, biocompatibility and cell uptake behaviour of the PhE-ITA-PEG nanoparticles were further evaluated to explore their potential biomedical applications. The results demonstrated that PhE-ITA-PEG could self-assemble to form uniform spherical nanoparticles with diameters ranging from 50 to 80 nm and showed high water dispersibility, intense yellow fluorescence quantum yield (38%) and excellent biocompatibility, which made them promising candidates for cell imaging. More importantly, the strategy of facile ring-opening PEGylation of 4-arm PEG-amine, itaconic anhydride, and an AIE monomer in this work will provide a new path to prepare more novel biocompatible AIE-based cross-linked fluorescent polymers, and would expand the range of their bio-applications.