文献类型：期刊文献

英文题名：Discovery of Highly Effective Antibacterial Agents Based on Chalcone-Benzisothiazolinone against Plant Pathogens

作者：Feng, Shuang Zhang, Miaohe Song, Junrong Ruan, Xianghui Xue, Wei

第一作者：冯双;Feng, Shuang

通信作者：Ruan, XH[1];Xue, W[1]

机构：[1]Guizhou Univ, Ctr R&D Fine Chem, State Key Lab Green Pesticide, Guiyang 550025, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550025, Peoples R China;[3]Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China;[4]Nat Prod Res Ctr Guizhou Prov, Guiyang 550014, Peoples R China

第一机构：Guizhou Univ, Ctr R&D Fine Chem, State Key Lab Green Pesticide, Guiyang 550025, Peoples R China

通信机构：corresponding author), Guizhou Univ, Ctr R&D Fine Chem, State Key Lab Green Pesticide, Guiyang 550025, Peoples R China.

年份：2024

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20245017514769);Scopus(收录号：2-s2.0-85211344518);WOS:【SCI-EXPANDED(收录号:WOS:001372608300001)】；

基金：The authors gratefully acknowledge the Science Foundation of Guizhou Province (No. ZK2024008), the Key Research and Development Program of Hainan Province (No. ZDYF2024XDNY202), the academic new seedling cultivation and exploration and innovation project of Guizhou Institute of Technology (No. GZLGXM-20), and the Young Science and Technology Talents Development Program of Education Department of Guizhou Province (No. KY2022346).

语种：英文

外文关键词：chalcone derivatives; antibacterial activity; plant bacterial disease; antibacterial mechanism

摘要：In this study, a series of novel chalcone compounds containing 1,2-benzisothiazolin-3-one were designed, synthesized, and screened for the prevention and control of plant bacterial diseases. The results showed that most of the target compounds displayed excellent antibacterial activities. Especially, F17 (2-(3-(4-cinnamoylphenoxy)propyl)benzo[d]isothiazol-3(2H)-one) exhibited remarkable efficacy against Xanthomonas oryzae pv Oryzae in vitro, with a half effective concentration (EC50) of 0.5 mu g/mL, better than that of the commercial antibacterial agent thiodiazole-copper (TC, 56.1 mu g/mL). Furthermore, F17 showed excellent effects against rice bacterial leaf blight in vivo, with protective and curative activities of 59.2% and 48.8% at 200 mu g/mL, respectively, which were higher than those of TC (38.3% and 36.6%). Moreover, the bacteriostatic mechanism of F17 was elucidated through a series of biochemical experiments. The results indicated that F17 could inhibit the expression of multiple pathogenic factors and induce the host's resistance to disease by enhancing the activities of defense enzymes. Therefore, F17, which revealed the ability to combat plant bacterial diseases by orchestrating the control of multiple factors, might provide a new perspective for solving the problem of plant pathogen resistance. Overall, the results of this work demonstrated that chalcone compounds containing benzisothiazolinone as highly effective antibacterial candidates hold potential for the management of plant bacterial diseases.