文献类型：期刊文献

英文题名：Antimicrobial Metabolites from the Freshwater Fungus Tubeufia longihelicospora Strain GZCC 23-0405

作者：Zhang, Lijuan Ma, Jian Zhao, Tianming Han, Meiyan Zheng, Dege Jayawardena, Ruvishika S. Mapook, Ausana Lu, Yongzhong

第一作者：张丽娟;Zhang, Lijuan

通信作者：Lu, YZ[1]

机构：[1]Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang 550003, Guizhou, Peoples R China;[2]Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand;[3]Mae Fah Luang Univ, Ctr Excellence Fungal Res, Chiang Rai 57100, Thailand

第一机构：贵州理工学院食品药品制造工程学院

通信机构：corresponding author), Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang 550003, Guizhou, Peoples R China.|贵州理工学院食品药品制造工程学院;贵州理工学院;

年份：2024

卷号：51

期号：4

外文期刊名：CHIANG MAI JOURNAL OF SCIENCE

收录：;Scopus(收录号：2-s2.0-85202158145);WOS:【SCI-EXPANDED(收录号:WOS:001266716900010)】；

基金：This work was funded by the National Natural Science Foundation of China (NSFC 32360011) and Youth Science and Technology Talent Development Project from Guizhou Provincial Department of Education [QJHKYZ (2022) 345] . Lijuan Zhang extends her heartfelt gratefulness to Mae Fah Luang University for granting her the tuition scholarship for her PhD studies. Ausana Mapook thanks the National Research Council of Thailand (NRCT) grant, entitled "Total fungal diversity in a given forest area with implications towards species numbers, chemical diversity and biotechnology" (Grant No. N42A650547) .r Development Project from Guizhou Provincial Department of Education [QJHKYZ (2022) 345] . Lijuan Zhang extends her heartfelt gratefulness to Mae Fah Luang University for granting her the tuition scholarship for her PhD studies. Ausana Mapook thanks the National Research Council of Thailand (NRCT) grant, entitled "Total fungal diversity in a given forest area with implications towards species numbers, chemical diversity and biotechnology" (Grant No. N42A650547) .

语种：英文

外文关键词：antimicrobial; freshwater fungi; secondary metabolites

摘要：In this study, five metabolites were successfully isolated from the culture medium of Tubeufia longihelicospora strain GZCC 23-0405, comprising two dimeric naphtha-gamma-pyrones (1-2), two dimeric coumarins (3-4), and one alkaloid (5). The elucidation of their chemical structures relied on a combination of NMR, MS, and optical rotation methods. Interestingly, these compounds represent the first instances of such metabolites being isolated from helicosporous hyphomycetes. Additionally, compounds (1) and (2) exhibited significant antimicrobial potential, with MIC and MBC values of 62.0 mu g mL-1 and 248 Fig mL-1, respectively, against Pseudomonas aeruginosa. This study provides a comprehensive account of the extraction, isolation, structural characterization, and antimicrobial properties of these compounds, shedding light on their potential significance in the field of natural product research.