文献类型：期刊文献

英文题名：Design, synthesis, biological activity evaluation and mechanism of action of myricetin derivatives containing thioether quinazolinone

作者：Liu, Tingting Peng, Feng Zhu, Yunying Cao, Xiao Wang, Qifan Liu, Fang Liu, Liwei Xue, Wei

第一作者：Liu, Tingting

通信作者：Xue, W[1]

机构：[1]Guizhou Univ, Res & Dev Ctr Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550001, Peoples R China

第一机构：Guizhou Univ, Res & Dev Ctr Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China

通信机构：corresponding author), Guizhou Univ, Res & Dev Ctr Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Peoples R China.

年份：2022

卷号：15

期号：8

外文期刊名：ARABIAN JOURNAL OF CHEMISTRY

收录：;EI(收录号：20222412209324);Scopus(收录号：2-s2.0-85131453049);WOS:【SCI-EXPANDED(收录号:WOS:000812286000011)】；

基金：Acknowledgements This research was completed with the support of the National Natural Science Foundation of China (No. 21867003) , the Science Foundation of Guizhou Province (No. 20192452) , Natural Science research project of Guizhou Education Department (No. 2018009) , Science and Technology Program of Guizhou Province (No. 20191139) , the Young Science and Technology Talents Development Program of Education Department of Guizhou Province (No. 2018251) .

语种：英文

外文关键词：Myricetin; Antibacterial; Antiviral; TMV CP; Chlorophyll content; Defensive enzyme activities; Quinazolinone

摘要：Plant bacteria and viruses have a huge negative impact on food crops in the world. Therefore, it is important to create new and efficient green pesticides. In this paper, a series of myricetin derivatives containing quinazolinone sulfide were introduced. Good antibacterial and antiviral activities of the drug molecules 2-((3-((5,7-dimethoxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-4Hchromen-3-yl)oxy)propyl)thio)-6-fluoro-3-phenylquinazolin-4(3H)-one (T5) and 2-((4-((5,7-dime thoxy-4-oxo-2-(3,4,5-trimethoxyphenyl)-4H-chromen-3-yl)oxy)butyl)thio)-6-methyl-3-phenylquina zolin-4(3H)-one (T15) respectively were found by biological activity screening. The value of dissociation constant (Kd) of compound T15 to TMV CP was 0.024 +/- 0.006 lM, determined by Microscale thermophoresis (MST), which was far less than the value of 8.491 +/- 2.027 lM of commercial drug ningnanmycin (NNM). The interaction between compound T15 and TMV CP was further verified by molecular docking. Compound T15 formed strong hydrogen bonds with residues SER:49 and SER:15 (1.92 A , 2.20 A , respectively), which were superior to the traditional hydrogen bonds formed by NNM with residue SER:215 (3.64 A ). In addition, the effects of compound T15 on the contents of chlorophyll and peroxidase (POD) in tobacco were studied, and the results indicated that compound T15 could enhance the disease resistance of tobacco plants to a certain extent. (c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).