文献类型：期刊文献

英文题名：Synthesis and Antibacterial Activity of Coumarin Derivatives Containing Benzene Sulfonate

作者：Bai, S. Wu, R. Wan, S. Chen, L. Lv, X. Xiao, Y. Wang, F. Wei, X. Li, M.

第一作者：Bai, S.

通信作者：Li, M[1]

机构：[1]Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;[2]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China;[3]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China.

年份：2025

卷号：95

期号：6

起止页码：1464-1475

外文期刊名：RUSSIAN JOURNAL OF GENERAL CHEMISTRY

收录：;Scopus(收录号：2-s2.0-105010009262);WOS:【SCI-EXPANDED(收录号:WOS:001521871500020)】；

基金：This research was supported by the following funds: Science and Technology Planning Project of Guizhou Province (grant no. Qian Ke He Ji Chu ZK [2022]Zhong Dian 025) and High School Science and Technology Talent Support Project of Guizhou Province, China (grant no. Qian Jiao He KY Zi [2021]037), those support the raw materials and reagents in the general synthesis of target compounds; Guizhou Provincial Department of Education Youth Science and Technology Talent Growth Project (grant no. Qian Jiao Ji [2024]293), which support the test cost for determining the structure of the relevant compound; Guizhou Industry Polytechnic College Science and Technology Innovation Team Project (grant no. 2023CXTD03) and Guizhou Provincial Department of Education Youth Science and Technology Talent Growth Project (grant no. Qian Jiao Ji [2024]292) provided materials and consumables for the biological activity of compounds. The following funds provided support for the experiments of conductivity and electron microscopy: Guizhou Industry Polytechnic College Faculty-level Research Project (grant nos. 2023ZK10 & 2023ZK11), High-Level Talent Initial Funding of Guizhou Industry Polytechnic College (grant no. 2023-RC-01), The Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University (grant no. Qian Jiao Ji [2022]433).

语种：英文

外文关键词：coumarins; benzene sulfonate; antibacterial activity; Xoc

摘要：Coumarin derivatives containing benzene sulfonate were designed and synthesized. Their anti-Xac, anti-Xoc and anti-Psa activities were studied systematically. It was found that these compounds had certain antibacterial activity against all three species of bacteria. Among them, 4-{[(6-nitro-2-oxo-2H-chromen-4-yl)amino]methyl}phenyl-3-chloro-2-fluorobenzenesulfonate had the best inhibitory activity against Xoc, with an EC50 value of 52.2 mg/L. The effect of this compound on the morphology and membrane of Xoc was studied by SEM and CM. It was found that this compound can affect the normal growth and development of Xoc.