文献类型：期刊文献

英文题名：Penicipyrrolizidinones A- C, three pyrrolizidinone alkaloids with unprecedented skeletons from the mangrove-derived fungus Penicillium sp. DM27

作者：Chen, Zhenling Zhang, Jing-Jing Huang, Cheng-Yun Chen, Wei-Chen He, Li-Ming Tang, Qing-Qing Zhu, Kong-Kai Li, Jing Gao, Ping Zhang, Meng-Ke Cai, You-Sheng

第一作者：陈振玲

通信作者：Gao, P[1];Cai, YS[1];Zhang, MK[2]

机构：[1]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550025, Peoples R China;[2]Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Nephrol, Wuhan 430071, Peoples R China;[3]Wuhan Univ, Dept Pharm, Renmin Hosp, Wuhan 430060, Peoples R China;[4]South Cent Minzu Univ, Sch Pharmaceut Sci, Wuhan 430079, Peoples R China;[5]Wuhan Univ, Sch Pharmaceut Sci, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China;[6]Shandong Univ, Adv Med Res Inst, Jinan 250012, Peoples R China

第一机构：贵州理工学院化学工程学院

通信机构：corresponding author), Wuhan Univ, Zhongnan Hosp, Sch Pharmaceut Sci, Dept Nephrol, Wuhan 430071, Peoples R China;corresponding author), Wuhan Univ, Dept Pharm, Renmin Hosp, Wuhan 430060, Peoples R China.

年份：2025

卷号：229

外文期刊名：PHYTOCHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001310873900001)】；

基金：This research was supported by the National Natural Science Foundation of China (82204225, 81973201) , the High Level Scientific Research Funding Project of Guizhou Institute of Technology (2023GCC024) , the Natural Science Foundation of Hubei Province (2021CFB061) , the Hubei Province Health and Family Planning Scientific Research Project (WJ2023M046) , the Science and Technology Plan Project of Guizhou Province (QiankeheJichu ZK [2024] yiban 519, ZK [2023] yiban 132) , the Academic New Seedling Plan Project of Guizhou Institute of Technology (GZLGXM-18) , the Open Project of Hubei Key Laboratory of Purification and Application of Plant Anti-Cancer Ingredients (HLPAI2023002) , and the Translational Medicine and Interdisciplinary Research Joint Fund Project of Zhongnan Hospital of Wuhan University (XKJC202313) . We thank Dr. Ran Zhang from the Core Facility of Wuhan University and Dr. Xue Zhou from the Core Research Facilities of CCMS (WHU) for their assistance with NMR analysis.

语种：英文

外文关键词：Penicillium sp. DM27; Mangrove-derived fungus; Pyrrolizidinone alkaloids; Pyrrolidine derivatives; Cytotoxicity; B16-F10 melanoma cells

摘要：Three previously undescribed pyrrolizidinone alkaloids, penicipyrrolizidinones A and B (1 and 2 ), possessing an unprecedented 2-methyl-2-(oct-6-enoyl)pyrrolizidin-3-one skeleton, and penicipyrrolizidinone C (3), featuring a rare 1-alkenyl-2-methyl-pyrrolizidin-3,7-dione skeleton, together with four known pyrrolidine derivatives (4-7) were isolated from the mangrove-derived fungus Penicillium sp. DM27. Their structures were elucidated through comprehensive spectroscopic analysis, theoretical calculations of ECD spectra, and the modified Mosher's method. A plausible biosynthetic pathway for penicipyrrolizidinones A-C (1-3) was proposed. Compounds 4 and 5 exhibited moderate cytotoxicity against B16-F10 melanoma cells with IC50 values of 10.5 mu M and 15.5 mu M, respectively.