文献类型：期刊文献

英文题名：Novel 1,3,4-oxadiazole sulfonate/carboxylate flavonoid derivatives: synthesis and biological activity

作者：Peng, Feng Liu, Tingting Zhu, Yunying Liu, Fang Cao, Xiao Wang, Qifan Liu, Liwei Xue, Wei

第一作者：Peng, Feng

通信作者：Xue, W[1];Xue, W[2];Xue, W[3]

机构：[1]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Peoples R China;[2]Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China;[3]Guizhou Univ, Res & Dev Ctr Fine Chem, Guiyang 550025, Peoples R China;[4]Guizhou Inst Technol, Sch Chem Engn, Guiyang, Peoples R China

第一机构：Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Peoples R China

通信机构：corresponding author), Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Peoples R China;corresponding author), Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China;corresponding author), Guizhou Univ, Res & Dev Ctr Fine Chem, Guiyang 550025, Peoples R China.

年份：0

外文期刊名：PEST MANAGEMENT SCIENCE

收录：;Scopus(收录号：2-s2.0-85139909736);WOS:【SCI-EXPANDED(收录号:WOS:000868784800001)】；

基金：This study was supported by the National Nature Science Foundation of China (No. 21867003), the Science Foundation of Guizhou Province (No. 20192452), Natural Science research project of Guizhou Education Department (No. 2018009), Science and Technology Program of Guizhou Province (No. 20191139), The Young Science and Technology Talents Development Program of Education Department of Guizhou Province (No. 2018251).

语种：英文

外文关键词：flavonoid derivatives; biological activity; SEM; microscale thermophoresis; TMV-CP

摘要：Background With the long-term use of traditional bactericides and antiviral agents, drug resistance has become increasingly prominent, resulting in impaired crop growth and yields. Based on this, the introduction of small molecular active groups into natural products has become the direction of research for green pesticides. Results In this study, novel 1,3,4-oxadiazole sulfonate/carboxylate flavonoid derivatives were explored. Among them, D4 exhibited good inhibitory effects on plant bacteria. It is worth mentioning that D4 (15 mu g ml(-1)) exhibited an excellent median effective concentration (EC50) value against Xanthomonas oryzae pv. oryzae (Xoo), which was better than bismerthiazol (73 mu g ml(-1)) and thiodiazole copper (100 mu g ml(-1)). The EC50 for D4 was much lower than the two positive controls (bismerthiazol, thiodiazole copper), making D4 more potent in this assay of bacterial growth inhibition. In addition, mechanism research using scanning electron microscopy revealed that D4 could cause deformation or rupture of the cell membranes of Xoo and Pseudomonas syringae pv. actinidiae. Moreover, D4 exhibited the best EC50 for in vivo curative (132 mu g ml(-1)) and protective (101 mu g ml(-1)) activities against tobacco mosaic virus, which were more effective than ningnanmycin. Microscale thermophoresis data suggested that D4 [dissociation constant (K-d) = 0.038 +/- 0.011 mu mol L-1] exhibited a stronger binding capacity than the control agent ningnanmycin (K-d = 4.707 +/- 2.176 mu mol L-1). Conclusion The biological activity data and mode of action demonstrated that D4 had the best antibacterial and antiviral effects. Compound D4 discovered in the current work may be a very promising agricultural drug. (c) 2022 Society of Chemical Industry.