文献类型：期刊文献

英文题名：Practical synthesis and divergent optimization of halichonine B for the discovery of novel pharmaceutical leads

作者：Hu, Nvdan Wang, Xia Sun, Shengxin Yang, Juan Li, Shengkun

第一作者：Hu, Nvdan

通信作者：Li, SK[1]

机构：[1]Guizhou Univ, Ctr R&D Fine Chem, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Peoples R China;[2]Guizhou Inst Technol, Coll Food & Pharmaceut Engn, Guiyang 550003, Peoples R China;[3]Nanjing Agr Univ, Coll Plant Protect, Dept Pesticide Sci, Nanjing 210095, Peoples R China

第一机构：Guizhou Univ, Ctr R&D Fine Chem, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Peoples R China

通信机构：corresponding author), Guizhou Univ, Ctr R&D Fine Chem, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Peoples R China.

年份：2023

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20235015227301);Scopus(收录号：2-s2.0-85179834968);WOS:【SCI-EXPANDED(收录号:WOS:001117752500001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (21977049), the National Key R&D Program of China (2022YFD1700300) and the Guizhou Provincial Science and Technology Projects (ZK[2023]Key Program 008).

语种：英文

外文关键词：Agricultural chemicals - Amides - Cell culture - Urea

摘要：The drimane sesquiterpene alkaloid halichonine B was isolated more than a decade ago, while only a very limited structure-activity relationship (SAR) was achieved in chemicobiology due to tedious synthesis (>10 steps) and inefficient modular derivatizations. Herein, a practical synthesis and divergent optimization of halichonine B is presented using the commercially inexpensive (+)-sclareolide, aiming at advancing chemicobiological exploration. Step-economic access (3 steps) to the core scaffold drimanyl amine was conceived and realized through an intramolecular Hofmann rearrangement, enabling a 6-step facile preparation of halichonine B. First agrochemical potential of this natural product and analogs was disclosed, facilitated by function-oriented rapid and modular diversifications including alkylated amines, amides, sulfamides, thioureas, and ureas. The unnatural mimic 10 and analog 12d were more effective against the cancer cell line HepG2 than cisplatin. The analog 12d was projected as a novel antifungal lead demonstrating >25-fold improvement than halichonine B against Rhizoctonia solani. Molecular docking differentiates halichonine B and the analog 12d by their interaction with the predictive target.