文献类型：期刊文献

英文题名：Synthesis and biological activity of novel sulfone derivatives containing a [1,2,4]triazolo[4,3-a]pyridine moiety

作者：Xu, Fang-Zhou Wang, Yan-Yan Zhu, Yun-Ying Shao, Jia-Hui Yu, Gang Xue, Wei Wu, Jian Wu, Hui-Bing Shi, Jun

第一作者：Xu, Fang-Zhou

通信作者：Wu, J[1]

机构：[1]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Res & Dev Ctr Fine Chem, Guiyang 550025, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang, Peoples R China;[3]Zaozhuang Univ, Coll Life Sci, Zaozhuang, Peoples R China

第一机构：Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Res & Dev Ctr Fine Chem, Guiyang 550025, Peoples R China

通信机构：corresponding author), Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ,Res & Dev Ctr Fine Chem, Guiyang 550025, Peoples R China.

年份：2017

卷号：192

期号：7

起止页码：850-855

外文期刊名：PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

收录：;Scopus(收录号：2-s2.0-85016446766);WOS:【SCI-EXPANDED(收录号:WOS:000405604900011)】；

基金：Financial assistance from the National Natural Science Foundation of China (Nos. 21562012, 21302025), the Special Funds for Training object of Outstanding Young Scientific & Technological Talents in Guizhou Province (No. 2015-15#), and the Science & Technology Foundation of Guizhou Province (J[2014]2056#) were appreciated.

语种：英文

外文关键词：Sulfone; [1,2,4]triazolo[4,3-a]pyridine; synthesis; antifungal activity; insecticidal activity

摘要：A series of novel sulfone derivatives containing a [1,2,4]triazolo[4,3-a]pyridine moiety was synthesized and characterized via H-1 NMR, C-13 NMR, IR, and elemental analyses. Bioassay results indicated some of the derivatives displayed good antifungal activities and insecticidal activity. The inhibition rates of 8-chloro-3-((2,6-difluorobenzyl)sulfonyl)-[1,2,4]triazolo[4,3-a]pyridine against Rhizotonia erealis and Helminthosporium maydis were 78.6% and 76.4% activities at 50g mL(-1), respectively. And compound 8-chloro-3-(((6-chloropyridin-3-yl)methyl)sulfonyl)-[1,2,4]triazolo[4,3-a]pyridine showed >95% mortality at 500g mL(-1) and >65% mortality at 200g mL(-1) against Plutella xylostella, respectively. As well as 8-chloro-3-(((6-chloropyridin-3-yl)methyl)sulfonyl)-[1,2,4]triazolo[4,3-a]pyridine displayed >90% mortality at 500g mL(-1) against Helicoverpa armigera. A preliminary structure activity relationship (SAR) is discussed. [GRAPHICS] .