文献类型：期刊文献

英文题名：A biomimetic bilayer fibrous scaffold for repair of massive rotator cuff tear via minimally invasive delivery

作者：Zou, Zhongfei Liu, Kai Cai, Fangyuan Huang, Xingke Shen, Zhen He, Yong Shen, Li Chen, Yuewei

第一作者：邹中妃

通信作者：Shen, L[1];Chen, YW[1];Chen, YW[2]

机构：[1]Guizhou Inst Technol, Sch Mech Engn, Guiyang 550003, Peoples R China;[2]Zhejiang Univ, Sch Mech Engn, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310027, Peoples R China;[3]Zhejiang Univ, Sch Mech Engn, Liangzhu Lab, Hangzhou 310027, Peoples R China;[4]Fudan Univ, Zhongshan Hosp, State Key Lab Cardiovasc Dis, Shanghai 200032, Peoples R China;[5]Guizhou Univ, Sch Mech Engn, Guiyang 550025, Peoples R China;[6]Shanghai Univ, Natl Ctr Translat Med Shanghai, SHU Branch, Shanghai 200444, Peoples R China

第一机构：贵州理工学院机械工程学院

通信机构：corresponding author), Fudan Univ, Zhongshan Hosp, State Key Lab Cardiovasc Dis, Shanghai 200032, Peoples R China;corresponding author), Guizhou Univ, Sch Mech Engn, Guiyang 550025, Peoples R China.

年份：2025

卷号：259

外文期刊名：MATERIALS & DESIGN

收录：;EI(收录号：20254019257385);Scopus(收录号：2-s2.0-105017228647);WOS:【SCI-EXPANDED(收录号:WOS:001587487300001)】；

基金：This work was sponsored by the National Natural Science Foundation of China (No. 52465035, 5256050459), the Science and Technology Planning Project of Guizhou Province (No. ZK[2024]510, No. ZK[2025] 615), Open Research (No.01) Fund of State Key Laboratory of Cardiovascular Diseases, Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems (GZKF-202404), Foundation of National Center for Translational Medicine (Shanghai) SHU Branch (SUITM-202504), Guizhou Institute of Technology High-level Talents Project (2023GCC031).

语种：英文

外文关键词：Minimally invasive; Rotator cuff tear; Tendon-bone interface; Melt electrowriting

摘要：Therapeutic arthroscopy is a common minimally invasive procedure, yet repairing massive rotator cuff tears remains challenging due to difficulties in delivering patches and replicating the complex tendon-bone interface. Herein, a clinical treatment strategy integrating customizable biomimetic structural scaffold with a novel minimally invasive delivery technique is proposed. First, inspired by the collagen fiber network of rotator cuff, a biomimetic bilayer heterogeneous fibrous scaffold was designed and fabricated. The tendon layer combines aligned and crimped fibers to replicate natural tendon collagen and guide tendon cell migration, while the bone repair layer features randomly-oriented crimped fibers to provide osteogenic topological cues. Results demonstrated that crimped (36.17 % porosity, 30-mu m pore diameter) and parallel-fibered (50-mu m spacing) scaffolds enhanced tendon stem cell adhesion and directional alignment compared to control groups. Second, a specialized minimally invasive delivery system was pioneered to transport a 50 x 30 mm scaffold to the intra-articular target site through a minimal incision (<= 10 mm), while preserving structural integrity and spatial orientation. Finally, arthroscopic simulations and implantation experiments validated the efficacy of this minimally invasive delivery strategy. This integrated solution for rotator cuff repair combines structural biomimetics, functional compatibility, and clinical feasibility, demonstrating strong translational potential.