文献类型：期刊文献

英文题名：Design, Synthesis, Antibacterial Activity, and Mechanism of Action of Coumarin Derivatives Containing Benzylamine

作者：Bai, Song Zhang, Miaohe Li, Miao Tang, Shouyin Wan, Suran Wang, Fang Wei, Xian Chen, Lijun Feng, Shuang Wu, Rong

第一作者：Bai, Song

通信作者：Wu, R[1];Wu, R[2]

机构：[1]Guizhou Ind Polytech Coll, Guiyang, Peoples R China;[2]Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang, Peoples R China;[3]Guizhou Inst Technol, Sch Chem Engn, Guiyang, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang, Peoples R China;corresponding author), Guizhou Univ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang, Peoples R China.

年份：2025

外文期刊名：CHEMISTRY & BIODIVERSITY

收录：;Scopus(收录号：2-s2.0-105002609345);WOS:【SCI-EXPANDED(收录号:WOS:001466000200001)】；

基金：This study was supported by Science and Technology Planning Project of Guizhou Province (Grant No. Qian Ke He Ji Chu ZK [2022] Zhong Dian 025), High School Science and Technology Talent Support Project of Guizhou Province, China (Grant No. Qian Jiao He KY Zi [2021]037), Guizhou Industry Polytechnic College Science and Technology Innovation Team Project (Grant No. 2023CXTD03), Guizhou Industry Polytechnic College Faculty-Level Research Project (Grant Nos. 2023ZK11 and 2023ZK10); the Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University (Grant No. Qian Jiao Ji [2022]433); the High-Level Talent Initial Funding of Guizhou Industry Polytechnic College (Grant No. 2023-RC-01); The Young Science and Technology Talents Development Program of Education Department of Gui-Zhou Province (Grant No. Qian Jiao He KY Zi [2022]346 Hao); the academic new seedling cultivation and exploration and innovation project of Guizhou Institute of Technology (No. GZLGXM-20); Basic Research Project of Guizhou Province (Grant No. Qian Ke He Ji Chu Zk [2025]Mian Shang 003); Guizhou Provincial Department of Education Youth Science and Technology Talent Growth Project (Grant No. Qian Jiao Ji [2024]292 Hao); Guizhou Industry Polytechnic College Faculty-level Research Project (Grant no. 2024zk18 & 2024zk19).

语种：英文

外文关键词：antibacterial activity; changes in cell morphology; coumarin derivatives

摘要：A series of novel coumarin derivatives were synthesized by successfully combining the coumarin backbone with benzylamine groups using active splicing technology and chemical synthesis. These derivatives demonstrated excellent antibacterial activity in vitro, with compound A5 being particularly prominent. Through three-dimensional quantitative structure-activity relationships (3D-QSAR) analysis, it was found that the introduction of an electron-donating group at the R1 position and a larger group at the R2 position could enhance the antibacterial activity, and the action mechanism of compound A5 was studied. The experimental results showed that A5 could increase the permeability of the bacterial membrane, thus disrupting the Xoo membrane and effectively inhibiting bacterial growth. This finding not only reveals the antibacterial mechanism of A5, but also provides an important scientific basis for the development of new antibacterial agents.