文献类型：期刊文献

英文题名：PROSPECTIVE ROLES OF IL-24 IN THE TUMORIGENESIS AND DEVELOPMENT OF CANCERS

作者：Huang, Lirong Wang, Bing Ma, Youfen Luo, Mei Sun, Baofei Luo, Heng

第一作者：黄丽荣;Huang, Lirong

通信作者：Luo, H[1];Luo, H[2];Luo, H[3]

机构：[1]Guizhou Inst Technol, Coll Food & Pharmaceut Engn, Guiyang, Peoples R China;[2]Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang, Peoples R China;[3]Key Lab Chem Nat Prod Guizhou Prov, Guiyang, Peoples R China;[4]Chinese Acad Sci, Guiyang, Peoples R China;[5]Guizhou Med Univ, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang, Peoples R China

第一机构：贵州理工学院食品药品制造工程学院

通信机构：corresponding author), Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang, Peoples R China;corresponding author), Key Lab Chem Nat Prod Guizhou Prov, Guiyang, Peoples R China;corresponding author), Chinese Acad Sci, Guiyang, Peoples R China.

年份：2021

卷号：78

期号：5

起止页码：599-611

外文期刊名：ACTA POLONIAE PHARMACEUTICA

收录：;Scopus(收录号：2-s2.0-85126627303);WOS:【SCI-EXPANDED(收录号:WOS:000746031800002)】；

基金：This work was supported by the Natural Science Foundations of China (81760573 and 81430077) , the Science and Technology Project of Guizhou Province (No.QKHLHZ [2016] 7092, No.LH [2015] 7345, No.QKHJC [2017] 1069, No. QKHJC [2017] 1412) .

语种：英文

外文关键词：IL-24; target therapy; tumorgenesis; tumor suppressor gene

摘要：Interleukin-24 (IL-24)/melanoma differentiation-associated gene-7 (mda-7), a novel tumor suppressor/cytokine, exerts tumor-selective inhibition of cells growth, induction of apoptosis, and suppression of angiogenesis in a broad spectrum of cancer cell types without harming the equivalent normal cells. Moreover, the low transcript levels and protein expression of IL-24 have been found to be significantly associated with unfavorable pathological phenotypes in breast cancer tissues. Furthermore, the ectopic expression of IL-24 in cancer cells via transfection with a plasmid comprising IL-24 cDNA or via administration of IL-24 containing recombinant adenovirus (Ad.IL-24) can effectively inhibit the growth and induce apoptosis in a wide array of cancer cells and rodent tumors both in vitro and in vivo. However, overexpression of IL-24 in normal primary cells does not elicit any effect on its growth and viability, indicating that IL-24 can act as a crucial target and therapeutic gene for cancer gene therapy. Mechanistically, the binding of IL-24 cytokine with its receptor pair in different tumor cells activates the JAK-STAT signal transduction pathway, serine/threonine-protein kinase (PKR) pathway, mitochondrial apoptosis signaling pathway, and inhibits CD31/PECAM pathway to inhibit cancer cell growth, induce apoptosis and regulate tumor vascularization. Herein, we reviewed the research progress on biochemical characteristics of IL-24 and its selective role in carcinogenesis, to provide a detailed understanding of the functional mechanism of IL-24. Overall, this study presented IL-24 as a potent antitumor drug target for the development of a more accurate therapeutic strategy and cancer gene therapy.