文献类型：期刊文献

英文题名：Asymmetric Mannich Reaction: Synthesis of Novel Chiral 5-(substituted aryl)-1,3,4-Thiadiazole Derivatives with Anti-Plant-Virus Potency

作者：Bai, Song Zhu, Yunying Wu, Qin

第一作者：柏松

通信作者：Bai, S[1];Bai, S[2]|[1444086c12c707ddfe99e]柏松;

机构：[1]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Guizhou, Peoples R China;[2]Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Guizhou, Peoples R China

第一机构：贵州理工学院化学工程学院

通信机构：corresponding author), Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Guizhou, Peoples R China;corresponding author), Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Guizhou, Peoples R China.|贵州理工学院化学工程学院;贵州理工学院;

年份：2019

卷号：25

期号：1

起止页码：47-51

外文期刊名：HETEROCYCLIC COMMUNICATIONS

收录：;Scopus(收录号：2-s2.0-85065671776);WOS:【SCI-EXPANDED(收录号:WOS:000467397300007)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grant No. 21602039), the Natural Science Foundation of Guizhou Province (Grant No. Qian Ke He Ji Chu[2017] 1066), and the Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University (Grant No. 2018GDGP0102), Science and Technology Program of Guizhou Province (Grant NO. Qian Ke He Ping Tai Ren Cai [2017] 5789).

语种：英文

外文关键词：anti-plant-virus activity; asymmetric Mannich reaction; chiral 1,3,4-thiadiazole derivatives

摘要：A series of novel chiral 5-(substituted aryl)-1,3,4-thiadiazole derivatives was synthesized in an enantioselective three-component Mannich reaction using cinchona alkaloid squaramide catalyst with excellent enantioselectivities (up to >99% enantiomeric excess (ee)). The bioas-say results showed that these derivatives possessed good to excellent activities against tobacco mosaic virus (TMV).