文献类型：期刊文献

英文题名：Facile fabrication of biocompatible polymeric microspheres using an AIE-active cellulose derivative for cell imaging

作者：Ma, Chunping He, Jiyin Xie, Gaoyi Han, Yuanyuan Lin, Fengyuan Guo, Qiankun Cao, Dongdong Mo, Jinpeng Ma, Haijun Xie, Haibo Chi, Zhenguo Jin, Yongcan

第一作者：Ma, Chunping

通信作者：Jin, YC[1];Xie, GY[2];Xie, HB[3]|[1444085b8499134be36d9]谢高艺;

机构：[1]Nanjing Forestry Univ, Coll Light Ind & Food Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing 210037, Peoples R China;[2]Wuyi Univ, Coll Text Sci & Engn, Jiangmen 529020, Peoples R China;[3]Guizhou Inst Technol, Sch Mat & Energy Engn, Guiyang 550003, Peoples R China;[4]Wuyi Univ, Sch Environm & Chem Engn, Jiangmen 529020, Peoples R China;[5]Ningxia Univ, Sch Life Sci, Minist Educ Protect & Utilizat Special Biol Resour, Key Lab, Yinchuan 750021, Peoples R China;[6]Guizhou Univ, Coll Mat & Met, Dept Polymer Mat & Engn, Guiyang 550025, Peoples R China

第一机构：Nanjing Forestry Univ, Coll Light Ind & Food Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing 210037, Peoples R China

通信机构：corresponding author), Nanjing Forestry Univ, Coll Light Ind & Food Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing 210037, Peoples R China;corresponding author), Wuyi Univ, Sch Environm & Chem Engn, Jiangmen 529020, Peoples R China;corresponding author), Guizhou Univ, Coll Mat & Met, Dept Polymer Mat & Engn, Guiyang 550025, Peoples R China.|贵州理工学院化学工程学院

年份：2025

卷号：239

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：20251318124574);Scopus(收录号：2-s2.0-105001042639);WOS:【SCI-EXPANDED(收录号:WOS:001458373600001)】；

基金：This research is supported by the Jiangsu Province Postdoctoral Research Funding Program (2019K045) , the Guangdong Province Rural Revitalization Strategy Special Fund (Jiangke [2021] 183) , the Guangdong Basic and Applied Basic Research Foundation (2022A1515010969) , the Wuyi University-Hong Kong/Macau Joint Research Funds (2021WGALH02) , the Science Foundation for Professor and Young Research Group of Wuyi University (JSQD2001, BSQD2016) and the Guizhou Province Science and Technology Planning Project ( (2019) 1419) .

语种：英文

外文关键词：Polymeric microspheres; Aggregation induced emission; Cell imaging biginelli reaction; Cellulose derivative

摘要：Fluorescent polymeric micromaterials have attracted abiding interest in biomedical applications due to their merits of visualization, fast response, and high sensitivity. Herein, we report a facile strategy for the fabrication of biocompatible polymeric microspheres using an aggregation-induced emission (AIE) active cellulose derivative TPE-CDHPM, which was synthesized through an esterification reaction of microcrystalline cellulose (MCC) and a subsequent Biginelli reaction. The chemical structures of TPE-CDHPM were determined by FT-IR and 1H NMR spectroscopies, displaying a high degree of substitution of TPE (DSTPE = 0.73). TPE-CDHPM showed extremely weak fluorescence in the mono-dispersed state while emitting intensively at aggregated state. When dispersed in water, TPE-CDHPM could aggregate into microspheres with a size range of 40-200 nm. The TPECDHPM microspheres exhibited an ultralow critical micelle concentration (CMC) of 0.006 mg mL- 1, good photoluminescence stability, negligible cytotoxicity, and fascinating biocompatibility, allowing its application in cell imaging. This work offers a direction for effectively constructing biocompatible fluorescent polymeric micromaterials for biomedical applications.