文献类型：期刊文献

英文题名：Synthesis and Bioactivities Study of Novel Pyridylpyrazol Amide Derivatives Containing Pyrimidine Motifs

作者：Wu, Wenneng Chen, Meihang Fei, Qiang Ge, Yonghui Zhu, Yingying Chen, Haijiang Yang, Maofa Ouyang, Guiping

第一作者：Wu, Wenneng

通信作者：Yang, MF[1];Ouyang, GP[1]

机构：[1]Guiyang Univ, Food & Pharmaceut Engn Inst, Guiyang, Peoples R China;[2]Guizhou Univ, Ctr Res & Dev Fine Chem, Sch Pharmaceut Sci, Entomol Inst, Guiyang, Peoples R China;[3]Tongren Coll, Mat & Chem Engn Inst, Tongren, Peoples R China;[4]Sch Chem Engn, Guizhou Inst Technol, Guiyang, Peoples R China

第一机构：Guiyang Univ, Food & Pharmaceut Engn Inst, Guiyang, Peoples R China

通信机构：corresponding author), Guizhou Univ, Ctr Res & Dev Fine Chem, Sch Pharmaceut Sci, Entomol Inst, Guiyang, Peoples R China.

年份：2020

卷号：8

外文期刊名：FRONTIERS IN CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85089534119);WOS:【SCI-EXPANDED(收录号:WOS:000562174900001)】；

基金：This research was financially supported by China Postdoctoral Science Foundation (No. 2017M623070), the National Natural Science Foundation of China (No. 31701821 and 21762037), the Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University (No. 2018GDGP0102), the Guizhou Province Biological and Pharmaceutical engineering Research Centerand (No. QJHKY[2019]051), and the special Funding of Guiyang Science and Technology Bureau and Guiyang University [GYU-KYZ(2019~2020)PT10-06].

语种：英文

外文关键词：pyridylpyrazol; amide; pyrimidine; antifungal activity; insecticidal activity

摘要：In this study, thirteen new pyridylpyrazolamide derivatives containing pyrimidine motifs were synthesized via six-step reactions. Bioassay results showed that some of the synthesized compounds revealed good antifungal properties againstSclerotinia sclerotiorum, Phytophthora infestans, Thanatephorus cucumeris, Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica, Botryosphaeria dothidea, andPhompsissp. at 50 mu g/mL, which were similar to those of Kresoxim-methyl or Pyrimethanil. Meanwhile, bioassay results indicated that the synthesized compounds showed a certain insecticidal activity againstSpodoptera litura, Mythimna separata, Pyrausta nubilalis, Tetranychus urticae, Rhopalosiphum maidis, andNilaparvata lugensat 200 mu g/mL, which was lower than that of Chlorantraniliprole. To the best of our knowledge, this study is the first report on the antifungal and insecticidal activities of pyridylpyrazol amide derivatives containing a pyrimidine moiety.