文献类型：期刊文献

英文题名：Design and synthesis of abietic acid derivatives containing sulfonamide structure, biological activity and mechanism of action studies

作者：Bai, Song Chen, Lijun Li, Miao Wan, Suran Wang, Fang Tang, Shouyin Wei, Xian Wu, Rong

第一作者：Bai, Song

通信作者：Wu, R[1]

机构：[1]Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang, Peoples R China;[3]Guizhou Univ, Minist Educ, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn, Guiyang, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China.

年份：2025

外文期刊名：JOURNAL OF SULFUR CHEMISTRY

收录：;EI(收录号：20252118474731);Scopus(收录号：2-s2.0-105005774086);WOS:【SCI-EXPANDED(收录号:WOS:001491412200001)】；

基金：The research is financially supported by the Science and Technology Planning Project of Guizhou Province [grant number Qian Ke He Ji Chu ZK [2022]Zhong Dian 025], High School Science and Technology Talent Support Project of Guizhou Province, China [grant number Qian Jiao He KY Zi [2021]037], Guizhou Industry Polytechnic College Science and Technology Innovation Team Project [grant number 2023CXTD03], Guizhou Provincial Department of Education Youth Science and Technology Talent Growth Project [grant number Qian Jiao Ji [2024]293 Hao], Guizhou Industry Polytechnic College Faculty-level Research Project [grant number 2023ZK10 & grant number 2023ZK11], The Young Science and Technology Talents Development Program of Education Department of Guizhou Province [grant NO. Qian Jiao He KY Zi [2022]346 Hao], High-Level Talent Initial Funding of Guizhou Industry Polytechnic College [grant number 2023-RC-01], The Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University [grant number Qian Jiao Ji [2022]433], Guizhou Industry Polytechnic College Faculty-level Research Project [grant number 2024zk18 & 2024zk19].

语种：英文

外文关键词：Abietic acid derivatives; antibacterial activity; changes in cell morphology; 3D-QSAR; Xoc

摘要：Through active splicing techniques and chemical synthesis methods, we have successfully synthesized a series of novel abietic acid derivatives that combine abietic acid backbone with a sulfonamide group. In vitro tests, these derivatives exhibited remarkable antibacterial activities, especially compound C3. Using three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis, we found that the introduction of electron-absorbing groups at the R1 position, as well as the introduction of larger groups at the R2 position, may enhance the antibacterial activity of the target compounds. In addition, studies on the antibacterial mechanism of action of compound C3 showed that it could increase the permeability of bacterial membranes, disrupt the cell membrane of Xanthomonas oryzae pv. oryzicola (Xoc), and effectively inhibit bacterial growth. These findings not only elucidate the antibacterial mechanism of C3, but also provide an important scientific basis for the design and development of new antibacterial agents.