文献类型：期刊文献

英文题名：Synthesis and antiviral activities of novel 1,4-pentadien-3-one derivatives bearing an emodin moiety

作者：Wu, Jian Zhu, Yun-Ying Zhao, Yong-Hui Shan, Wei-Li Hu, De-Yu Chen, Ji-Xiang Liu, Deng-Yue Li, Xiang-Yang Yang, Song

第一作者：Wu, Jian

通信作者：Wu, J[1]

机构：[1]Guizhou Univ, Res & Dev Ctr Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550001, Peoples R China;[3]Minist Agr, Inst Control Agrochem, Beijing 100125, Peoples R China

第一机构：Guizhou Univ, Res & Dev Ctr Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Peoples R China

通信机构：corresponding author), Guizhou Univ, Res & Dev Ctr Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Peoples R China.

年份：2016

卷号：27

期号：6

起止页码：948-952

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;Scopus(收录号：2-s2.0-84960156776);WOS:【SCI-EXPANDED(收录号:WOS:000379271500029)】；

基金：We gratefully acknowledge financial assistance from the National Natural Science Foundation of China (No. 21302025), the Special Funds for Training object of Outstanding Young Scientific & Technological Talents in Guizhou Province (No. 2015-15#), and the Science & Technology Foundation of Guizhou Province (No. J[2014]2056#).

语种：英文

外文关键词：1,4-Pentadien-3-one derivatives; Emodin; Synthesis; Antiviral activity

摘要：A series of 1,5-diary1-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination,of natural products. The antiviral activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) In vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mu g/mL, which was superior to ningnanmycin (409.3 mu g/mL). (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier. B.V. All rights reserved.