文献类型：期刊文献

英文题名：Neogrisphenol A, a Potential Ovarian Cancer Inhibitor from a New Record Fungus Neohelicosporium griseum

作者：Zhang, Li-Juan Yang, Ming-Fei Ma, Jian Xiao, Xing-Juan Ma, Xiao-Yan Zheng, De-Ge Han, Mei-Yan Xia, Ming-Lei Jayawardena, Ruvishika S. Mapook, Ausana Xiao, Yuan-Pin Kang, Ji-Chuan Lu, Yong-Zhong

第一作者：Zhang, Li-Juan;张丽娟

通信作者：Lu, YZ[1];Kang, JC[2];Lu, YZ[2]

机构：[1]Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang 550003, Peoples R China;[2]Mae Fah Luang Univ, Ctr Excellence Fungal Res, Chiang Rai 57100, Thailand;[3]Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand;[4]Guizhou Univ, Engn & Res Ctr Southwest Biopharmaceut Resources N, Guiyang 550025, Peoples R China;[5]Guizhou Univ, Coll Life Sci, Guiyang 550025, Peoples R China;[6]Guiyang Healthcare Vocat Univ, Dept Hlth Management, Guiyang 550081, Peoples R China

第一机构：贵州理工学院食品药品制造工程学院

通信机构：corresponding author), Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang 550003, Peoples R China;corresponding author), Guizhou Univ, Engn & Res Ctr Southwest Biopharmaceut Resources N, Guiyang 550025, Peoples R China.|贵州理工学院食品药品制造工程学院;贵州理工学院;

年份：2023

卷号：13

期号：3

外文期刊名：METABOLITES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000959006100001)】；

语种：英文

外文关键词：saprophytic fungi; helicosporous hyphomycetes; polyketide derivatives; antimicrobials; cytotoxicity

摘要：From the rice fermentation product of a new record fungus, Neohelicosporium griseum, two new polyketides, neogrisphenol A (1) and neogrisphenol B (2), one new isochroman-1-one, (S)-6-hydroxy-7-methoxy-3,5-dimethylisochroman-1-one (3), and four known compounds (4-7) were isolated. Their structures were determined using 1D- and 2D-NMR, mass spectrometry, and chemical calculations. The C-3 similar to C-2 ' polymerization mode between the two alpha-naphthalenone derivative moieties is uncommon in compounds 1 and 2. Meanwhile, compounds 1-2 and 5 exhibited antibacterial activity against Bacillus subtilis, Clostridium perfringens, Staphylococcus aureus, and Staphylococcus aureus, with MIC values ranging between 16 and 31 mu g/mL. In addition, compound 5 showed antifungal activity against Sclerotinia sclerotiorum and Phytophthora nicotianae var. nicotianae, with respective IC50 values of 88.14 +/- 2.21 mu g/mL and 52.36 +/- 1.38 mu g/mL. Compound 1 showed significant cytotoxicity against A2780, PC-3, and MBA-MD-231 cell lines with respective IC50 values of 3.20, 10.68, and 16.30 mu M, and the cytotoxicity against A2780 cells was even higher than that of cisplatin (CDDP). With an IC50 value of 10.13 mu M, compound 2 also exhibited cytotoxicity against A2780. The in vitro results showed that compound 1 inhibited A2780 cell proliferation, induced apoptosis, and arrested the cell cycle at the S-phase in a concentration-dependent manner.