文献类型：期刊文献

英文题名：Protein-based nano delivery systems focusing on protein materials, fabrication strategies and applications in ischemic stroke intervention: A review

作者：Yan, Chao Zhu, Xuchun Ren, Yingying Guan, Shanyue He, Shan Qiu, Feng Huang, Mingzheng Qu, Xiaozhong Liu, Hongzhi

第一作者：Yan, Chao

通信作者：Liu, HZ[1];Qu, XZ[2];Guan, SY[3]

机构：[1]Beijing Technol & Business Univ, Sch Food & Hlth, Key Lab Geriatr Nutr & Hlth, Haidian 100080, Peoples R China;[2]Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China;[3]Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China;[4]Peoples Liberat Army Gen Hosp, Sr Dept Neurol, Med Ctr 1, Beijing 100036, Peoples R China;[5]Guizhou Inst Technol, Guizhou 550000, Peoples R China

第一机构：Beijing Technol & Business Univ, Sch Food & Hlth, Key Lab Geriatr Nutr & Hlth, Haidian 100080, Peoples R China

通信机构：corresponding author), Beijing Technol & Business Univ, Sch Food & Hlth, Key Lab Geriatr Nutr & Hlth, Haidian 100080, Peoples R China;corresponding author), Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China;corresponding author), Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China.

年份：2025

卷号：311

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;EI(收录号：20251818348307);Scopus(收录号：2-s2.0-105003974920);WOS:【SCI-EXPANDED(收录号:WOS:001487108800003)】；

基金：This work was supported by National Natural Science Foundation of China (ID 32472269) , Guizhou Provincial Science and Technology Department (KXJZ [2024] 021) , Beijing High-level Talent Project (ID 19008024075) , Youth Innovation Promotion Association of Chinese Academy of Sciences (No. 2019027) and Beijing Natural Science Foundation (7244312) .

语种：英文

外文关键词：Protein-based nanocarriers; Fabrication strategies; Surface modification; Ischemic stroke; Neuroprotection

摘要：Ischemic stroke (IS), characterized by acute cerebral vascular occlusion and narrow therapeutic windows, poses formidable clinical challenges due to the blood-brain barrier (BBB) restriction, reperfusion injury risks, and limited efficacy of conventional thrombolytic therapies. These hurdles necessitate advanced delivery systems capable of precise BBB penetration, remodeled circulation, and neuroprotection. Proteins and peptides emerge as universal biomaterials for constructing nano-delivery platforms, leveraging their biocompatibility, biodegradability, low toxicity, and receptor-specific targeting. This review systematically explores protein-based nanomaterials in stroke intervention, emphasizing material selection, fabrication strategies, and therapeutic applications. Various structural proteins are analyzed for their unique advantages in carrier design, while peptide modifications are highlighted for enhancing targeted delivery. Critical fabrication techniques are discussed to balance stability and functionality. Furthermore, the applications of protein-based nanomaterials in IS therapy are summarized. Advanced preparation and application of protein-based nanomaterials, from delivery vehicles to ligand modification, potentially prolong the therapeutic window for IS and provide effective neuroprotection.