文献类型：期刊文献

中文题名：山楂叶总黄酮双层缓释片的研制

英文题名：Development of sustained release bilayer tablets of total flavonoids from hawthorn leaves

作者：郭东贵 左安刚 王慧娟 周英

第一作者：郭东贵

机构：[1]贵州理工学院制药工程学院;[2]贵州大学药学院

第一机构：贵州理工学院食品药品制造工程学院

年份：2016

卷号：27

期号：7

起止页码：1641-1643

中文期刊名：时珍国医国药

外文期刊名：Lishizhen Medicine and Materia Medica Research

收录：北大核心:【北大核心2014】；CSCD:【CSCD_E2015_2016】；

基金：贵州省中药现代化科技产业研究开发专项[黔科合社字(2008)5024号];贵州省中药现代化专项[黔科合中药字【2012】5040号]

语种：中文

中文关键词：山楂叶总黄酮;双层缓释片;制备;释放度

外文关键词：Hawthorn leaves total flavonoids; Sustained release bilayer tablets; Preparation; Release rate

摘要：目的山楂叶总黄酮双层缓释片的制备研究。方法双层缓释片由速释层和缓释层两部分组成。以释放度为考察指标,考察不同种类的辅料及其用量,确定最佳处方。结果山楂叶总黄酮双层缓释片质量稳定,其最优处方为速释层:3.2%山楂叶提取物,22%MCC,1.1%c CMC-Na(内加),2.1%c CMC-Na(外加),11.2%淀粉,0.4%硬脂酸镁;缓释层:16%山楂叶提取物,24%HPMCK4M,3%CMC-Na,16.4%MCC,0.6%硬脂酸镁。结论山楂叶总黄酮双层缓释片处方合理,质量可控,是值得开发的产品。
Objective To screen the optimal formula for sustained release bilayer tablet of total flavonoids. Methods Sustained release bilayer tablet consists of a rapid release layer and a slow release layer. Different kinds of excipients in the formulation were selected and their dosage was optimized by examining the dissolution rate. Results The optimal formulation was as follows： the rapid release layer contained 3. 2% total flavonoid extracts of hawthorn leaves,22% of MCC,1. 1% of c CMC- Na（ add within）,2. 1% of c CMC- Na（ plus）,11. 2% of starch,and0. 6% of magnesium stearate,while the slow release layer contained16% of hawthorn leaves total flavonoids,24% of HPMCK4 M,3% of CMC- Na,16. 4% of MCC,and 0. 6% of magnesium stearate. Conclusion The as- prepared sustained release bilayer tablet is a promising formulation with reliable therapeutic effects.