文献类型：期刊文献

中文题名：Synthesis and antiviral activities of novel 1,4-pentadien-3-one derivatives bearing an emodin moiety

英文题名：Synthesis and antiviral activities of novel 1,4-pentadien-3-one derivatives bearing an emodin moiety

作者：Jian Wu Yun-Ying Zhu Yong-Hui Zhao Wei-Li Shan De-Yu Hu Ji-Xiang Chen Deng-Yue Liu Xiang-Yang Li Song Yang

第一作者：Jian Wu

机构：[1]State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University;[2]School of Chemical Engineering, Guizhou Institute of Technology;[3]Institute for the Control of Agrochemicals, Ministry of Agriculture

第一机构：State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University

年份：2016

卷号：0

期号：6

起止页码：948-952

中文期刊名：中国化学快报：英文版

收录：CSTPCD;;Scopus;CSCD:【CSCD2015_2016】；PubMed;

基金：assistance from the National Natural Science Foundation of China (No. 21302025);the Special Funds for Training object of Outstanding Young Scientific & Technological Talents in Guizhou Province (No. 2015-15#);the Science & Technology Foundation of Guizhou Province (No. J[2014]2056#)

语种：英文

中文关键词：抗病毒活性;酮类衍生物;大黄素;合成;戊二烯;黄瓜花叶病毒;烟草花叶病毒;天然产品

外文关键词：1; 4-Pentadien-3-one derivatives; Emodin; Synthesis; Antiviral activity;

摘要：A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus(TMV) and cucumber mosaic virus(CMV) in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mg/m L, which was superior to ningnanmycin(409.3 mg/m L).
A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus（TMV） and cucumber mosaic virus（CMV） in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mg/m L, which was superior to ningnanmycin（409.3 mg/m L）.