文献类型：期刊文献

英文题名：Four New Dibenzo-α-pyrones From Helicosporium sexuale LZ15

作者：Zhang, Lijuan Ma, Xiaoyan Han, Meiyan Zheng, Dege Ma, Jian Xiao, Xingjuan Xiao, Yuanpin Jayawardena, Ruvishika S. Mapook, Ausana Hyde, Kevin David Lu, Yongzhong

第一作者：Zhang, Lijuan;张丽娟

通信作者：Lu, YZ[1];Lu, YZ[2]

机构：[1]Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang, Guizhou, Peoples R China;[2]Guizhou Acad Agr Sci, Guizhou Key Lab Agr Microbiol, Guiyang, Peoples R China;[3]Mae Fah Luang Univ, Sch Sci, Chiang Rai, Thailand;[4]Mae Fah Luang Univ, Ctr Excellence Fungal Res, Chiang Rai, Thailand;[5]Chiang Mai Univ, Excellence Ctr Microbial Divers & Sustainable Util, Chiang Mai, Thailand;[6]Qujing Normal Univ, Coll Biol & Food Engn, Ctr Yunnan Plateau Biol Resources Protect & Utiliz, Qujing, Peoples R China;[7]Qujing Normal Univ, Coll Biol & Food Engn, Yunnan Int Joint Lab Fungal Sustainable Utilizat S, Qujing, Peoples R China;[8]Guizhou Ind Polytech Coll, Guiyang, Guizhou, Peoples R China

第一机构：贵州理工学院食品药品制造工程学院

通信机构：corresponding author), Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang, Guizhou, Peoples R China;corresponding author), Guizhou Acad Agr Sci, Guizhou Key Lab Agr Microbiol, Guiyang, Peoples R China.|贵州理工学院食品药品制造工程学院;贵州理工学院;

年份：2026

卷号：23

期号：4

外文期刊名：CHEMISTRY & BIODIVERSITY

收录：;Scopus(收录号：2-s2.0-105036565546);WOS:【SCI-EXPANDED(收录号:WOS:001747765200001)】；

基金：This study was supported by the National Natural Science Foundation of China (NSFC 32360011) and the Science and Technology programs of Guizhou Province {Qian Ke He Basic Research (MS)[2026] 262, Qian Ke He Pingtai ZSYS [2025]029; KXJZ [2024]021}, Guizhou Provincial Science and Technology Support Program (General Project) [2023] No. 069, as well as the Start-up Project for High-Level Talent Research of Guizhou Institute of Technology (2023GCC069). Li-Juan Zhang gratefully acknowledges the tuition fee scholarship from Mae Fah Luang University.

语种：英文

外文关键词：cytotoxicity; dibenzo-alpha-pyrones; Helicosporium sexuale

摘要：Four new dibenzo-alpha-pyrone derivatives-helicolide A (1) and helicohydrins B-D (2-4)-along with five known analogues (5-9) were isolated from the fermented rolled-oat culture of Helicosporium sexuale LZ15. Their structures were determined by comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS) and further confirmed by x-ray crystallography, NOE correlations, and ECD calculations. Structurally, helicolide A (1) is an isocoumarin derivative bearing carboxyl and acetyl groups, while Helicohydrins B-D (2-4) are polyhydroxylated fused isocoumarins. In vitro cytotoxicity assays revealed that compound 5 showed moderate cytotoxicity toward HeLa cells; compound 6 displayed moderate activity against HepG2 and HeLa; compound 7 exhibited weak cytotoxicity toward A2780 and A549; and compound 8 moderately inhibited A549 and weakly inhibited HeLa cells.