文献类型：期刊文献

英文题名：Design, Synthesis, and Biological Evaluation of Novel 1,4-Pentadien-3-one Derivatives Containing a Sulfonamide Moiety

作者：Zhou, Qing Zhou, Yuanxiang Zhu, Yunying Gong, Chenyu Wu, Yongjun Xue, Wei

第一作者：Zhou, Qing

通信作者：Xue, W[1];Wu, YJ[2]

机构：[1]Guizhou Univ, Res & Dev Ctr Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Minist Educ,Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Guizhou, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550001, Guizhou, Peoples R China;[3]Guizhou Univ, Inst Agrobioengn, Coll Life Sci, Guiyang 550025, Guizhou, Peoples R China

第一机构：Guizhou Univ, Res & Dev Ctr Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Minist Educ,Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Guizhou, Peoples R China

通信机构：corresponding author), Guizhou Univ, Res & Dev Ctr Fine Chem, State Key Lab Breeding Base Green Pesticide & Agr, Minist Educ,Key Lab Green Pesticide & Agr Bioengn, Guiyang 550025, Guizhou, Peoples R China;corresponding author), Guizhou Univ, Inst Agrobioengn, Coll Life Sci, Guiyang 550025, Guizhou, Peoples R China.

年份：2022

卷号：70

期号：51

起止页码：16096-16105

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20225213289048);Scopus(收录号：2-s2.0-85144365869);WOS:【SCI-EXPANDED(收录号:WOS:000933934000001)】；

基金：The authors gratefully acknowledge the National Natural Science Foundation of China (32072446) , the Science Foundation of Guizhou Province (20192452) , the Natural Science Research Project of Guizhou Education Department (2018009) , the Science and Technology Program of Guizhou Province (20191139) , and the Young Science and TechnologyTalents Development Program of Education Department of Guizhou Province (2018251) .

语种：英文

外文关键词：1; 4-pentadien-3-one; sulfonamide moiety; antifungal; antibacterial; antiviral

摘要：Novel 1,4-pentadien-3-one derivatives containing a sulfonamide moiety were synthesized, and their antifungal, antibacterial, and antiviral activities were verified. These compounds exhibited better activity against five bacteria, with EC50 values ranging from 9.6 to 60.1 mu g/mL, prominently, which are superior to those of the commercial agent. A great amount of compounds had excellent fungicidal activity in vitro at 100 mu g/mL. Strikingly, compound E6 exhibited moderate activity against Phytophthora litchii than azoxystrobin, with the EC50 value of compound E6 (0.5 mu g/mL) drawing near azoxystrobin (0.3 mu g/mL). Furthermore, compound E17 had a marked impact on in vivo anti-tobacco mosaic virus, according to the data of microscale thermophoresis, with a Kd value of the intermolecular binding force of 0.002 +/- 0.001 mu M, which was better than the commercial agent of ningnanmycin (Kd = 0.121 +/- 0.031 mu M). In addition, the results of these studies suggest that the use of active splicing can improve the biological activity of natural compounds and provide further complement to the development of novel pesticides.