文献类型：期刊文献

英文题名：A Novel Nitrogen-containing Glyceride from Fungal Saprobe Tubeufia rubra Reverses MDR of Tumor Cell Lines to Doxorubicin

作者：Zeng, Xuebo Qian, Shengyan Lu, Yongzhong Li, Yongjie Chen, Lizhuang Qian, Yixin He, Zhangjiang Kang, Jichuan

第一作者：Zeng, Xuebo

通信作者：Kang, JC[1]

机构：[1]Guizhou Univ, Sch Pharmaceut Sci, Guiyang 550025, Guizhou, Peoples R China;[2]Guizhou Univ, Engn & Res Ctr Southwest Biopharmaceut Resources, Natl Educ Minist China, Guiyang 550025, Guizhou, Peoples R China;[3]Guizhou Univ, Sch Life Sci, Guiyang 550025, Guizhou, Peoples R China;[4]Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang 550003, Guizhou, Peoples R China

第一机构：Guizhou Univ, Sch Pharmaceut Sci, Guiyang 550025, Guizhou, Peoples R China

通信机构：corresponding author), Guizhou Univ, Engn & Res Ctr Southwest Biopharmaceut Resources, Natl Educ Minist China, Guiyang 550025, Guizhou, Peoples R China.

年份：0

外文期刊名：RECORDS OF NATURAL PRODUCTS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000790287200001)】；

基金：This study was supported by the National Natural Science Foundation of China (NSFC No.31670027, 32170019, 32160667, and 31901947) and the Open Fund Program of Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of National Education Ministry of China, Guizhou University. No. GZUKEY20160.

语种：英文

外文关键词：Rubracin A; Tubeufia rubra PF02-2; cytotoxic activity; MDR reversal

摘要：A Abstract: A chemical investigation of secondary metabolites from the saprobic fungus Tubeufia rubra led to isolation of a novel nitrogen-containing glyceride, Rubracin A (1), and a novel eight-membered cyclic ether carboxylate methyl ester, Rubracin H (2). Together with six known compounds (3-8). The chemical structure of these new compounds were elucidated by 1D and 2D NMR and HR-ESI-MS techniques. Although, there are no observed cytotoxic effects of compound 1 against MCF-7/Dox, A549/Dox, and K562/Dox cells at oncentrations below 25 mu g/mL, usage of compound 1 and doxorubicin revealed the MDR reversal via decreased IC50 values than that of sole doxorubicin application in the cell lines. A preliminary Western Blot assay indicated that the MDR reversal of compound 1 was due to suppression of P-glycoprotein (P-gp) expression.