文献类型：期刊文献

英文题名：Current applications of poly(lactic acid) composites in tissue engineering and drug delivery

作者：Liu, Shan Qin, Shuhao He, Min Zhou, Dengfeng Qin, Qingdong Wang, Hao

第一作者：刘松

通信作者：Liu, S[1];Wang, H[2]

机构：[1]Guizhou Inst Technol, Coll Mat & Energy Engn, Guiyang 550003, Peoples R China;[2]Guizhou Inst Technol, Key Lab Light Met Mat Proc Technol Guizhou Prov, Guiyang 550003, Peoples R China;[3]Natl Engn Res Ctr Compounding & Modificat Polymer, Guiyang 550014, Peoples R China;[4]Guizhou Univ, Coll Mat & Met, Dept Polymer Mat & Engn, Guiyang 550025, Peoples R China;[5]Univ Southern Queensland, Ctr Future Mat, Toowoomba, Qld 4350, Australia

第一机构：贵州理工学院

通信机构：corresponding author), Guizhou Inst Technol, Coll Mat & Energy Engn, Guiyang 550003, Peoples R China;corresponding author), Univ Southern Queensland, Ctr Future Mat, Toowoomba, Qld 4350, Australia.|贵州理工学院;

年份：2020

卷号：199

外文期刊名：COMPOSITES PART B-ENGINEERING

收录：;EI(收录号：20203209018256);Scopus(收录号：2-s2.0-85088916372);WOS:【SCI-EXPANDED(收录号:WOS:000571425200003)】；

基金：The authors gratefully acknowledge financial support from Science and Technology Foundation of Guizhou Province (grant No. Qiankehe [2020]1Y213) and the Startup Foundation for Introducing Talent of Guizhou Institute of Technology (grant No. XJGC20190917).

语种：英文

外文关键词：Poly(lactic acid); Biocomposite; Tissue engineering; Drug delivery; Fabrication; Scaffold

摘要：Biodegradable poly(lactic acid) (PLA) presents suitable physicochemical properties and biocompatibility for biomedical engineering. However, PLA has some drawbacks, such as low cell adhesion, biological inertness, low degradation rate, and acid degradation by-products. In this review, recent progress on strategies to address these problems is summarized, including novel fabrication techniques, high-performance PLA composites, and their applications for tissue engineering and drug delivery. The scaffolds, especially for bone regeneration, blood vessels, organs, and skin regeneration are evaluated, in terms of in vivo and in vitro biocompatibility and biodegradability. The enhanced mechanical, thermal, and rheological properties of PLA biocomposites are analyzed in detail. PLA biocomposites for drug encapsulation, sustained release, and tumor-targeting are also reviewed. Furthermore, the challenges and future perspectives on PLA-based biocomposites are discussed.