文献类型：期刊文献

英文题名：New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity

作者：Ran, Jingyu Wang, Cong Zhang, Jinjuan Wang, Wei Xiao, Lihua Jia, Shaoyi Wang, Ze Wu, Weidang Xiao, Jun Wu, Xinyu

第一作者：Ran, Jingyu;冉景榆

通信作者：Ran, JY[1];Ran, JY[2];Wu, WD[3];Wu, WD[4]

机构：[1]Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Guizhou, Peoples R China;[3]Guizhou Med Univ, Sch Basic Med Sci, Basic Med Expt Teaching Ctr, Guiyang 550025, Guizhou, Peoples R China;[4]Tianjin Inst Pharmaceut Res Co Ltd, State Key Labs Drug Delivery Technol & Pharmacoki, Tianjin 300193, Peoples R China;[5]Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China;[6]Guizhou Med Univ, Sch Biol & Engn, Guiyang 550025, Guizhou, Peoples R China;[7]Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Guizhou, Peoples R China

第一机构：Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

通信机构：corresponding author), Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China;corresponding author), Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Guizhou, Peoples R China;corresponding author), Tianjin Inst Pharmaceut Res Co Ltd, State Key Labs Drug Delivery Technol & Pharmacoki, Tianjin 300193, Peoples R China;corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China.|贵州理工学院化学工程学院;贵州理工学院;

年份：2018

卷号：10

期号：5

外文期刊名：POLYMERS

收录：;EI(收录号：20181805133272);Scopus(收录号：2-s2.0-85046303293);WOS:【SCI-EXPANDED(收录号:WOS:000435199300014)】；

基金：We gratefully thank Zhongkai Cui (University of California Los Angeles, United States) and Guangshen Du (Leiden University, The Netherlands) for their help in discussions. This work was supported by the Guizhou Province Science and Technology Department-Guizhou Institute of Technology Joint Fund (Guizhou Science and Technology Agency LH [2015]7097), and the National Natural Science Foundation of China (No. 51776046).

语种：英文

外文关键词：polydopamine; ZIF-8; Zinc-releasing; anticancer activity

摘要：Despite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy (TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous media within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of dopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional membranes during the release of zinc. More interestingly, PDA@ZIF-8-based nanohybrids expressed stronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug carrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides a versatile strategy toward the development of multifunctional delivery system.