文献类型：期刊文献

英文题名：Effects and Impact of Selenium on Human Health, A Review

作者：Bai, Song Zhang, Miaohe Tang, Shouying Li, Miao Wu, Rong Wan, Suran Chen, Lijun Wei, Xian Feng, Shuang

第一作者：柏松

通信作者：Tang, SY[1]

机构：[1]Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China;[2]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Peoples R China;[3]Guizhou Univ, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

第一机构：Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China

通信机构：corresponding author), Guizhou Ind Polytech Coll, Guiyang 550008, Peoples R China.

年份：2025

卷号：30

期号：1

外文期刊名：MOLECULES

收录：;Scopus(收录号：2-s2.0-85214480626);WOS:【SCI-EXPANDED(收录号:WOS:001393629200001)】；

基金：This research was funded by the Science and Technology Planning Project of Guizhou Province (Grant No. Qian Ke He Ji Chu ZK [2022] Zhong Dian 025); the High School Science and Technology Talent Support Project of Guizhou Province, China (Grant No. Qian Jiao He KY Zi [2021]037); the Guizhou Industry Polytechnic College Faculty-level Research Project (Grant No. 2023ZK10); the Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University (Grant No. Qian Jiao Ji [2022]433); the Guizhou Industry Polytechnic College Science and Technology Innovation Team Project (Grant No. 2023CXTD03); the Guizhou Industry Polytechnic College Faculty-level Research Project (Grant No. 2023ZK11); the High-Level Talent Initial Funding of Guizhou Industry Polytechnic College (Grant No. 2023-RC-01); the Young Science and Technology Talents Development Program of Education Department of Guizhou Province (Grant NO. Qian Jiao He KY Zi [2022]0-346 Hao); the Academic New Seedling Cultivation and Exploration and Innovation Project of Guizhou Institute of Technology (No. GZLGXM-20).

语种：英文

外文关键词：selenium; selenoproteomics; glutathione peroxidases; thioredoxin reductases; iodothyronine deiodinases; human health

摘要：Selenium (Se) is an essential trace element that is crucial for human health. As a key component of various enzymes and proteins, selenium primarily exerts its biological functions in the form of selenoproteins within the body. Currently, over 30 types of selenoproteins have been identified, with more than 20 of them containing selenocysteine residues. Among these, glutathione peroxidases (GPXs), thioredoxin reductases (TrxRs), and iodothyronine deiodinases (DIOs) have been widely studied. Selenium boasts numerous biological functions, including antioxidant properties, immune system enhancement, thyroid function regulation, anti-cancer effects, cardiovascular protection, reproductive capability improvement, and anti-inflammatory activity. Despite its critical importance to human health, the range between selenium's nutritional and toxic doses is very narrow. Insufficient daily selenium intake can lead to selenium deficiency, while excessive intake carries the risk of selenium toxicity. Therefore, selenium intake must be controlled within a relatively precise range. This article reviews the distribution and intake of selenium, as well as its absorption and metabolism mechanisms in the human body. It also explores the multiple biological functions and mechanisms of selenium in maintaining human health. The aim is to provide new insights and evidence for further elucidating the role of selenium and selenoproteins in health maintenance, as well as for future nutritional guidelines and public health policies.