文献类型：期刊文献

英文题名：Antiviral Bioactivity of Chiral -Amino Acid Ester Derivatives Synthesized through a One-Pot, Solvent-Free Asymmetric Mannich Reaction

作者：Bai, Song Liu, Shan Zhu, Yunying Zhao, Kunhong Wu, Qin

第一作者：柏松

通信作者：Bai, S[1];Bai, S[2]|[1444086c12c707ddfe99e]柏松;

机构：[1]Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Guizhou, Peoples R China;[2]Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 5500, Guizhou, Peoples R China;[3]Guiyang Municipal Publ Secur Bur, Drug Identificat Ctr, Guiyang 550081, Guizhou, Peoples R China

第一机构：贵州理工学院化学工程学院

通信机构：corresponding author), Guizhou Inst Technol, Sch Chem Engn, Guiyang 550003, Guizhou, Peoples R China;corresponding author), Guizhou Univ, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 5500, Guizhou, Peoples R China.|贵州理工学院化学工程学院;贵州理工学院;

年份：2018

卷号：29

期号：14

起止页码：1921-1925

外文期刊名：SYNLETT

收录：;Scopus(收录号：2-s2.0-85051961237);WOS:【SCI-EXPANDED(收录号:WOS:000442304600021)，CCR-EXPANDED(收录号:WOS:000442304600021)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grant No. 21602039), Natural Science Foundation of Guizhou Province, China (Grant No. Qian Ke He Ji Chu[2017]1066), the Opening Foundation of the Key Laboratory of Green Pesticide and Agricultural Bioengineering, the Ministry of Education, Guizhou University (Grant No. 2016GDGP0103), and the Research Center for Microreaction Engineering of Guizhou Colleges and Universities (Grant No. Qian Jiao He KY Zi[2015]339).

语种：英文

外文关键词：one-pot; solvent-free; chiral -amino ester derivatives; Mannich reaction; antiviral bioactivity

摘要：A series of both enantiomers of chiral -amino acid ester derivatives containing a 4-(piperidin-1-yl)pyrimidine moiety was prepared in high yield and excellent enantioselectivity excess (up to >99% enantiomeric excess) using a chiral cinchona alkaloid thiourea catalyst under one-pot solvent-free conditions. Antiviral bioassay experimental results showed that some of the chiral products exhibited higher antiviral activities against tobacco mosaic virus (TMV) in vivo than the commercial antiviral agent ningnanmycin.