文献类型：期刊文献

英文题名：Bio-inspired metamaterial structured small-diameter vascular grafts for emulation of native arterial mechanics

作者：Cai, Xianhui Zou, Zhongfei Shen, Zhen Guo, Rui Yu, Xiong Zhu, Xuanrong Shen, Li Li, Jiachun Chen, Yuewei

第一作者：Cai, Xianhui

通信作者：Li, JC[1];Chen, YW[1];Zou, ZF[2];Chen, YW[3];Chen, YW[4];Chen, YW[5]

机构：[1]Guizhou Univ, Sch Mech Engn, Guiyang 550025, Peoples R China;[2]Guizhou Inst Technol, Sch Mech Engn, Guiyang 550003, Peoples R China;[3]Fudan Univ, Zhongshan Hosp, State Key Lab Cardiovasc Dis, Shanghai 200032, Peoples R China;[4]Zhejiang Univ, Sch Mech Engn, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310027, Peoples R China;[5]Zhejiang Univ, Sch Mech Engn, Liangzhu Lab, Hangzhou 310027, Peoples R China

第一机构：Guizhou Univ, Sch Mech Engn, Guiyang 550025, Peoples R China

通信机构：corresponding author), Guizhou Univ, Sch Mech Engn, Guiyang 550025, Peoples R China;corresponding author), Guizhou Inst Technol, Sch Mech Engn, Guiyang 550003, Peoples R China;corresponding author), Fudan Univ, Zhongshan Hosp, State Key Lab Cardiovasc Dis, Shanghai 200032, Peoples R China;corresponding author), Zhejiang Univ, Sch Mech Engn, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310027, Peoples R China;corresponding author), Zhejiang Univ, Sch Mech Engn, Liangzhu Lab, Hangzhou 310027, Peoples R China.|贵州理工学院机械工程学院;贵州理工学院;

年份：2026

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20261820617077);Scopus(收录号：2-s2.0-105037154398);WOS:【SCI-EXPANDED(收录号:WOS:001751363800001)】；

基金：This work was supported by the the National Natural Science Foundation of China (Grant No. 52465035, 52565030, 52565008, and T2288101), the Science and Technology Planning Project of Guizhou Province (Grant No. MS[2025]615 and ZK[2024]510), the High-level Talents Project of Guizhou Institute of Technology (2023GCC031), the Introduced Talents Research Project of Guizhou University (GDRJHZ-202416), the Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems (GZKF-202511), the Open Research Fund (No. 01) of the State Key Laboratory of Cardiovascular Diseases, the National Health Commission Scientific Research Fund-Zhejiang Provincial Major Science and Technology Program for Health (WKJ-ZJ-2507), and the Higher Education Engineering Research Center of Guizhou Province (QJJ [2023]040).

语种：英文

外文关键词：Biomimetics - Blood - Blood vessel prostheses - Blood vessels - Fabrication - Grafts - Hydrogels - Metamaterials - Morphology - Scaffolds - Scaffolds (biology) - Structural design

摘要：To address the issue that the mechanical strength and compliance of traditional small-diameter artificial blood vessels are difficult to balance, leading to easy thrombosis and subsequent failure after transplantation, this study, inspired by the corrugated structure of collagen fibers, designs and fabricates a metamaterial composite tubular small-diameter artificial blood vessel. This design employs a gelatin-based hydrogel as the matrix phase to simulate the extracellular matrix of natural arteries, leveraging its high biocompatibility. The reinforcement phase is an ultra-fine fiber network with a metamaterial structure manufactured by high-precision 3D printing; this network mimics the curled morphology of collagen fibers and endows the composite tubular scaffold with the ability to reproduce the J-shaped stress-strain characteristics of natural arteries. Meanwhile, by adjusting the parameters of the metamaterial structural units, the axial modulus and burst resistance strength of the composite tubular scaffold can be regulated within the ranges of 0.091-0.55 MPa and 820-3250 mmHg, respectively, thereby matching the mechanical strength of natural arteries in various parts of the human body. On the basis of meeting high mechanical strength requirements, the design of the metamaterial structure enables the compliance of the composite tubular scaffold to be adjusted within the range of 6.25-13.28%, achieving compliance matching with natural arteries. This research provides an idea for the design and fabrication of artificial blood vessels.