文献类型：期刊文献

英文题名：One-pot synthesis of benzimidazole-pyrazines and their anticancer activities

作者：Li, Yingfen Wei, Xian Bai, Song Xu, Zhi-Gang Lv, Menglan

通信作者：Lv, ML[1]

机构：[1]Guizhou Inst Technol, Sch Chem Engn, Caiguan Rd, Guiyang 550003, Guizhou, Peoples R China;[2]Chongqing Univ Arts & Sci, Int Acad Targeted Therapeut & Innovat, Chongqing, Peoples R China

第一机构：贵州理工学院化学工程学院

通信机构：corresponding author), Guizhou Inst Technol, Sch Chem Engn, Caiguan Rd, Guiyang 550003, Guizhou, Peoples R China.|贵州理工学院化学工程学院;贵州理工学院;

年份：2019

卷号：56

期号：12

起止页码：3429-3434

外文期刊名：JOURNAL OF HETEROCYCLIC CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85074879678);WOS:【SCI-EXPANDED(收录号:WOS:000494862800001)】；

基金：Natural Science Research Project of Education Department of Guizhou, China, Grant/Award Number: QJHKY [2018]242; Excellent Young Scientific and Technological Talents of Guizhou, China, Grant/Award Number: QKHPTRC [2019]5652; Natural Science Foundation of China, Grant/Award Number: 51863002

语种：英文

摘要：The skeleton of fused benzimidazole-pyrazine was constructed via an Ugi/deprotection/cyclization (UDC) and hydroamination cascade reaction. This four-step reaction was carried out in a one-pot procedure with only one-time column chromatography purification. The representative compound 7b exhibited 67% cell growth inhibitory activity against human breast cancer cell line MDA-MB-453 at the concentration of 10 mu M.