文献类型：期刊文献

英文题名：Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation

作者：Zhang, Lijuan Ma, Jian Yang, Mingfei Zhao, Tianming Han, Mei Yan Zheng, Dege Mapook, Ausana Lu, Yongzhong Jayawardena, Ruvishika S.

第一作者：Zhang, Lijuan;张丽娟

通信作者：Jayawardena, RS[1];Jayawardena, RS[2];Lu, YZ[3];Jayawardena, RS[4]

机构：[1]Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand;[2]Mae Fah Luang Univ, Ctr Excellence Fungal Res, Chiang Rai 57100, Thailand;[3]Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang 550025, Peoples R China;[4]Guiyang Healthcare Vocat Univ, Dept Hlth Management, Guiyang 550081, Peoples R China;[5]Kyung Hee Univ, 26 Kyungheedae Ro, Seoul 02447, South Korea

第一机构：Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand

通信机构：corresponding author), Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand;corresponding author), Mae Fah Luang Univ, Ctr Excellence Fungal Res, Chiang Rai 57100, Thailand;corresponding author), Guizhou Inst Technol, Sch Food & Pharmaceut Engn, Guiyang 550025, Peoples R China;corresponding author), Kyung Hee Univ, 26 Kyungheedae Ro, Seoul 02447, South Korea.|贵州理工学院食品药品制造工程学院;贵州理工学院;

年份：2024

卷号：33

期号：2

起止页码：308-313

外文期刊名：MEDICINAL CHEMISTRY RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001136126000001)】；

基金：LZ would like to express her gratitude to Mae Fah Luang University for providing a scholarship for her PhD studies. RSJ thanks Eminent Scholar offered by Kyun Hee University.

语种：英文

外文关键词：Helicosporous hyphomycetes; Natural product; Polyketones; Saprophytic fungi; Secondary metabolites

摘要：In the pursuit of discovering new active metabolites from helicosporous hyphomycetes, rice fermentation products of Neohelicosporium griseum were examined. Eight compounds were isolated from this saprophytic fungus, namely vertixanthone (1), diaportheone A (2), 1,3,6,8-tetrahydroxyanthraquinone (3), lecanoric acid (4), decarboxycitrinone (5), 6,8-dihydroxy-4-hydroxymethyl-3,5-dimethyl-isochromen-1-one (6), decarboxyhydroxycitrinone (7), and ergosterin (8). The 1D and 2D NMR characteristics of compound 1 in DMSO-d(6) were detailed for the first time. Antimicrobial testing indicated that compounds 1-4 exhibited moderate activity against Pseudomonas aeruginosa, with compound 3 also showing weak activity against Staphylococcus aureus. In-vitro cytotoxicity assays revealed that compounds 1, 3, and 4 displayed cytotoxic activity against HELA cell lines, with respective IC50 values of 30.8, 13.7, and 14.1 mu M. Compounds 1, 3, and 4 also showed significant cytotoxicity against A549 cell lines, with respective IC50 values of 24.7, 7.4, and 10.3 mu M.